CST, 81935S, KCTD12 (D8V4J) Rabbit Monoclonal Antibody

Monoclonal Antibody for studying KCTD12. Validated for Western Blotting,Immunoprecipitation. Available in 2 sizes. Highly specific and rigorously validated in-house, KCTD12 (D8V4J) Rabbit Monoclonal Antibody (CST #81935) is ready to ship. Product Usage Information Western Blotting: 1:1000 Immunoprecipitation: 1:50 Storage Supplied in 10 mM sodium HEPES (pH 7.5), 150 mM NaCl, 100 µg/ml BSA, 50% glycerol and less than 0.02% sodium azide. Store at -20°C. Do not aliquot the antibody. Protocol Available protocols: Western Blotting, Immunoprecipitation Specificity / Sensitivity KCTD12 (D8V4J) Rabbit Monoclonal Antibody recognizes endogenous levels of total KCTD12 protein. Species Reactivity: Human, Mouse Source / Purification Monoclonal antibody is produced by immunizing animals with a synthetic peptide corresponding to residues surrounding Pro177 of human KCTD12 protein. Background Potassium channel tetramerization domain-containing protein 12 (KCTD12) belongs to the family of KCTD proteins, which also contains KCTD8, 12b, and 16. These proteins are auxiliary subunits of GABAB receptors (1). The principal subunit of the GABA receptor is formed by two GABA receptors, which bind to GABA ligands, couple to G proteins to inhibit adenylate cyclase production, and gate ion channels (e.g., the GIRK channels) (2). The auxiliary subunits contribute to receptor desensitization. KCTD12 produces fast desensitization by uncoupling the βγ subunits of the G protein from their effector channels (3). Research studies indicate that KCTD12 represents a biomarker with diagnostic and prognostic potential for gastrointestinal stromal tumors (4). Alternate Names BTB/POZ domain-containing protein KCTD12; C13orf2; FLJ33073; KCD12; KCTD12; KIAA1778; PFET1; Pfetin; potassium channel tetramerisation domain containing 12; potassium channel tetramerization domain containing 12; Predominantly fetal expressed T1 domain; testicular tissue protein Li 100 Specification REACTIVITY: H M SENSITIVITY: Endogenous MW (kDa): 33 Source/Isotype: Rabbit IgG