CST, 81945T, CEACAM7 (E5Q6X) Rabbit Monoclonal Antibody

Monoclonal Antibody for studying CEACAM7. Validated for Western Blotting,Immunohistochemistry (Paraffin). Available in 2 sizes. Highly specific and rigorously validated in-house, CEACAM7 (E5Q6X) Rabbit Monoclonal Antibody (CST #81945) is ready to ship. Product Usage Information Western Blotting: 1:1000 Immunohistochemistry (Paraffin): 1:200 - 1:800 Storage Supplied in 10 mM sodium HEPES (pH 7.5), 150 mM NaCl, 100 µg/mL BSA, 50% glycerol, and less than 0.02% sodium azide. Store at -20°C. Do not aliquot the antibody. For a carrier free (BSA and azide free) version of this product see product # 34209 . Protocol Available protocols: Western Blotting, Immunohistochemistry (Paraffin) Specificity / Sensitivity CEACAM7 (E5Q6X) Rabbit Monoclonal Antibody recognizes endogenous levels of total CEACAM7 protein. Species Reactivity: Human Source / Purification Monoclonal antibody is produced by immunizing animals with a synthetic peptide corresponding to residues surrounding Val141 of human CEACAM7 protein. Background Carcinoembryonic antigen (CEA)-related cell adhesion molecule 7 (CEACAM7) is a homodomeric glycoprotein that is covalently linked to the plasma membrane via a GPI anchor and modulates cell adhesion via its N-terminal IgV domain (1). In normal human tissues, CEACAM7 expression is largely restricted to epithelial cells of the colon and pancreatic ducts (2). While some research studies have demonstrated that CEACAM7 expression is downregulated in human colorectal carcinomas, other studies have highlighted high expression levels in some pancreatic ductal adenocarcinomas (PDAC) (3-5). Given the restricted expression pattern in normal human tissues, CEACAM7 is positioned as an attractive immunotherapeutic target for PDAC (4). Alternate Names Carcinoembryonic antigen CGM2; carcinoembryonic antigen gene family member 2; carcinoembryonic antigen related cell adhesion molecule 7; Carcinoembryonic antigen-related cell adhesion molecule 7; CEA; CEA cell adhesion molecule 7; CEACAM7; CEAM7; CGM2 Specification REACTIVITY: H SENSITIVITY: Endogenous MW (kDa): 55 Source/Isotype: Rabbit IgG