CST, 82400S, beta-Synuclein (F8O8P) Rabbit Monoclonal Antibody

Monoclonal Antibody for studying synuclein-beta. Validated for Immunofluorescence (Frozen). Available in 2 sizes. Highly specific and rigorously validated in-house, beta-Synuclein (F8O8P) Rabbit Monoclonal Antibody (CST #82400) is ready to ship. Product Usage Information Immunofluorescence (Frozen): 1:800 - 1:1600 Storage Supplied in 10 mM sodium HEPES (pH 7.5), 150 mM NaCl, 100 µg/mL BSA, 50% glycerol, and less than 0.02% sodium azide. Store at -20°C. Do not aliquot the antibody. For a carrier free (BSA and azide free) version of this product see product # 33431 . Protocol Available protocols: Immunofluorescence (Frozen) Specificity / Sensitivity beta-Synuclein (F8O8P) Rabbit Monoclonal Antibody recognizes endogenous levels of total β-synuclein protein. This antibody does not cross-react with α-synuclein. Species Reactivity: Mouse Source / Purification Monoclonal antibody is produced by immunizing animals with a synthetic peptide corresponding to residues surrounding Pro90 of human β-synuclein protein. Background The synuclein family, consisting of α-synuclein, β-synuclein, and γ-synuclein, is a group of small, soluble proteins containing a highly conserved α-helical lipid-binding motif. α-synuclein and β-synuclein are primarily expressed in brain tissue, where they colocalize within presynaptic terminals (1,2). α-synuclein is linked genetically and neuropathologically to Parkinson's disease and other neurodegenerative diseases, called synucleinopathies, characterized by the presence of intracellular α-synuclein aggregates, the main component of Lewy bodies (3,4). β-synuclein has been shown to inhibit α-synuclein aggregation and ameliorate α-synuclein neurotoxicity (5-7). Studies have shown that β-synuclein levels are elevated in early and advanced Alzheimer's disease, Creutzfeldt-Jakob disease, and traumatic brain injury, showing strong potential for use as a synaptic damage biomarker (8-9). Alternate Names Beta-synuclein; I(2)-synuclein; SNCB; synuclein beta; synuclein, beta; SYUB Specification REACTIVITY: M SENSITIVITY: Endogenous MW (kDa): 18 Source/Isotype: Rabbit IgG