CST, 83346S, KU-55933

Chemical Modulators for studying in the research area. Product Usage Information KU-55933 is supplied as a lyophilized powder. For a 10 mM stock, reconstitute 5 mg of powder in 1.26 ml of DMSO. Working concentrations and length of treatment can vary depending on the desired effect. Storage Store lyophilized at -20ºC, desiccated. In lyophilized form, the chemical is stable for 24 months. Once in solution, store at -20ºC and use within 1 month to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles. Background KU-55933 is a potent and selective ATP-competitive inhibitor of ATM kinase (IC = 13 nM and K = 2.2 nM). This small molecule has been shown to sensitize cancer cells to ionizing radiation and chemotherapeutic agents (1). Treating senescent cancer cells (MCF7, A549, and HCT 116) with KU-55933 results in decreased viability and cell death (2). KU-55933 has neuroprotective capabilities by preventing damage caused by oxidative stress (3). Alternate Names 2-(4-Morpholinyl)-6-(1-thianthrenyl)-4H-pyran-4-one; ATM Kinase Inhibitor; competitive ATM kinase inhibitor; KU-55933; KU-55933 (ATM Kinase Inhibitor); KU55933