CST, 83912S, LAMB1 (F1Q8V) Rabbit Monoclonal Antibody

Monoclonal Antibody for studying LAMB1. Validated for Western Blotting,Immunoprecipitation. Highly specific and rigorously validated in-house, LAMB1 (F1Q8V) Rabbit Monoclonal Antibody (CST #83912) is ready to ship. Product Usage Information Western Blotting: 1:1000 Immunoprecipitation: 1:50 Storage Supplied in 10 mM sodium HEPES (pH 7.5), 150 mM NaCl, 100 µg/mL BSA, 50% glycerol, and less than 0.02% sodium azide. Store at -20°C. Do not aliquot the antibody. Protocol Available protocols: Western Blotting, Immunoprecipitation Specificity / Sensitivity LAMB1 (F1Q8V) Rabbit Monoclonal Antibody recognizes endogenous levels of total LAMB1 protein. Species Reactivity: Human, Mouse Source / Purification Monoclonal antibody is produced by immunizing animals with a synthetic peptide corresponding to residues surrounding Leu1690 of human LAMB1 protein. Background Laminin Subunit Beta-1 (LAMB1) is a protein that is a part of the laminin family, which are extracellular matrix glycoproteins. Laminins are major components of basement membranes and play a critical role in cell adhesion, differentiation, migration, and phenotype stability. LAMB1 is involved in the assembly and stability of the basement membrane, which is a specialized sheet-like structure that surrounds muscle, fat, and nerve cells. It lines the surface of other cells, such as endothelial cells that line blood vessels (1). Mutations in the gene can lead to developmental abnormalities and diseases. For example, upregulation of LAMB1 promotes cell proliferation, invasion, and migration in gastric cancer (2). Furthermore, mutations are associated with cobblestone brain malformation, pain sensitivity, and blood-brain-barrier integrity (3-5). Alternate Names CLM; cutis laxa with marfanoid phenotype; LAMB1; Laminin B1 chain; laminin subunit beta 1; Laminin subunit beta-1; Laminin-1 subunit beta; Laminin-10 subunit beta; Laminin-12 subunit beta; Laminin-2 subunit beta; Laminin-6 subunit beta; Laminin-8 subunit beta; laminin, beta 1; LIS5; MGC142015 Specification REACTIVITY: H M SENSITIVITY: Endogenous MW (kDa): 200 Source/Isotype: Rabbit IgG