CST, 84031SF, TNFRSF17/BCMA (E6D7B) Rabbit Monoclonal Antibody (BSA and Azide Free)

Monoclonal Antibody for studying TNFRSF17. Validated for WB,IHC,IHC,F. Highly specific and rigorously validated in-house, TNFRSF17/BCMA (E6D7B) Rabbit Monoclonal Antibody (BSA and Azide Free) (CST #84031) is ready to ship. Product Usage Information This product is the carrier-free version of product #88183. All data were generated using the same antibody clone in the standard formulation which contains BSA and glycerol. This formulation is ideal for use with technologies requiring specialized or custom antibody labeling, including fluorophores, metals, lanthanides, and oligonucleotides. It is not recommended for ChIP, ChIP-seq, CUT&RUN, or CUT&Tag assays. If you require a carrier-free formulation for chromatin profiling, please contact us . Optimal dilutions/concentrations should be determined by the end user. BSA and Azide Free antibodies are quality control tested by size exclusion chromatography (SEC) to determine antibody integrity. Formulation Supplied in 1X PBS (10 mM Na 2 HPO 4 , 3 mM KCl, 2 mM KH 2 PO 4 , and 140 mM NaCl (pH 7.8)). BSA and Azide Free. For standard formulation of this product see product # 88183 . Storage Store at -20°C. This product will freeze at -20°C so it is recommended to aliquot into single-use vials to avoid multiple freeze/thaw cycles. A slight precipitate may be present and can be dissolved by gently vortexing. This will not interfere with antibody performance. Specificity / Sensitivity TNFRSF17/BCMA (E6D7B) Rabbit Monoclonal Antibody (BSA and Azide Free) recognizes endogenous levels of total TNFRSF17/BCMA protein. This antibody displays some non-specific staining of peripheral and CNS tissue when used for IHC-P. Species Reactivity: Human Source / Purification Monoclonal antibody is produced by immunizing animals with a synthetic peptide corresponding to residues surrounding Leu115 of human TNFRSF17/BCMA protein. Background B cell maturation antigen (BCMA/TNFRSF17/CD269) is a transmembrane glycoprotein and member of the TNFR superfamily (1). BCMA expression is largely restricted to the B cell lineage. Pro-survival signaling through this receptor plays a pivotal role in humoral immunity by regulating B cell maturation and plasma cell differentiation upon binding its ligands, BAFF and APRIL (2-6). BCMA is expressed in a number of B cell malignancies and has garnered much attention as a novel therapeutic target for the treatment of multiple myeloma due to its selective and elevated expression on the cell surface of malignant plasma cells (7-10). Alternate Names B cell maturation antigen; B-cell maturation factor; B-cell maturation protein; BCM; BCMA; CD269; TNF receptor superfamily member 17; TNFRSF13A; TNFRSF17; TNR17; Tumor necrosis factor receptor superfamily member 17; tumor necrosis factor receptor superfamily, member 17 Specification REACTIVITY: H SENSITIVITY: Endogenous MW (kDa): 18-30 Source/Isotype: Rabbit IgG