CST, 84093S, ST2 (F9H6V) Rabbit Monoclonal Antibody

Monoclonal Antibody for studying IL1RL1. Validated for Western Blotting. Available in 2 sizes. Highly specific and rigorously validated in-house, ST2 (F9H6V) Rabbit Monoclonal Antibody (CST #84093) is ready to ship. Product Usage Information Western Blotting: 1:1000 Storage Supplied in 10 mM sodium HEPES (pH 7.5), 150 mM NaCl, 100 µg/mL BSA, 50% glycerol, and less than 0.02% sodium azide. Store at -20°C. Do not aliquot the antibody. Protocol Available protocols: Western Blotting Specificity / Sensitivity ST2 (F9H6V) Rabbit Monoclonal Antibody recognizes endogenous levels of total ST2 protein. Species Reactivity: Human Source / Purification Monoclonal antibody is produced by immunizing animals with a recombinant fragment specific to the central region of human ST2 protein. Background ST2 is a component of the interleukin-33 (IL-33) receptor, which is a heterodimer of ST2 and IL-1 receptor accessory protein (IL1RAP) (1). ST2 is expressed on various types of immune cells, including several types of T cells, group 2 innate lymphoid cells (ILC2s), NK cells, and myeloid cells, as well as on cardiomyocytes, microglia, and astrocytes (2,3). Its ligand, IL-33, is expressed by endothelial and epithelial cells, and functions as an alarmin (4,5). ST2 is activated in response to allergens and parasites, leading to signaling via MyD88, which results in activation of NF-κB and AP-1, inducing production of IL-4, IL-5, and IL-13 (4). Aberrant signaling along the IL-33/ST2 axis has been implicated in asthma and chronic obstructive pulmonary disease (COPD), with anti-IL-33 and anti-ST2 therapeutics both under investigation for clinical use (6,7). Alternate Names DER4; FIT-1; growth stimulation-expressed; homolog of mouse growth stimulation-expressed; IL1RL1; IL33R; ILRL1; interleukin 1 receptor like 1; interleukin 1 receptor-like 1; interleukin 1 receptor-related protein; Interleukin-1 receptor-like 1; MGC32623; Protein ST2; ST2; ST2L; ST2V; T1 Specification REACTIVITY: H SENSITIVITY: Endogenous MW (kDa): 55-75 Source/Isotype: Rabbit IgG