CST, 84321S, Factor XIIIA (E980.1) Mouse Monoclonal Antibody

Monoclonal Antibody for studying F13A1. Validated for IHC Leica Bond,Immunohistochemistry (Paraffin). Available in 2 sizes. Highly specific and rigorously validated in-house, Factor XIIIA (E980.1) Mouse Monoclonal Antibody (CST #84321) is ready to ship. Product Usage Information IHC Leica Bond: 1:50 - 1:200 Immunohistochemistry (Paraffin): 1:100 - 1:400 Storage Supplied as liquid tissue culture supernatant containing sodium azide as a preservative. Stable for 12 months when stored at 4°C. Do not aliquot the antibody. Note: This product is only available in the format listed above. We are unable to provide this in a carrier free, custom formulation. Protocol Available protocols: IHC Leica Bond, Immunohistochemistry (Paraffin) Specificity / Sensitivity Factor XIIIA (E980.1) Mouse Monoclonal Antibody recognizes endogenous levels of Factor XIIIA protein. Species Reactivity: Human Source / Purification Monoclonal antibody is produced by immunizing animals with a prokaryotic recombinant protein corresponding to a portion of the C-terminus of the blood coagulation factor XIIIa protein. Background Factor XIIIA, or fibrin stabilizing factor, is activated by thrombin and Ca to a protransglutaminase in the final step of the blood coagulation cascade that cross-links fibrin chains (1). This enzyme catalyzes the gamma-glutamyl-epsilon-lysine cross-linking between fibrin molecules, stabilizing the fibrin clot (1,2). It is widely expressed in dermal dendritic cells (3). High expression of Factor XIIIA positive cells can be indicative of inflammatory conditions such as lichen planus and psoriasis (4). Alternate Names bA525O21.1 (coagulation factor XIII, A1 polypeptide); Coagulation factor XIII A chain; coagulation factor XIII A1 subunit; coagulation factor XIII, A polypeptide; coagulation factor XIII, A1 polypeptide; Coagulation factor XIIIa; F13A; F13A1; factor XIIIa; fibrin stabilizing factor, A subunit; fibrinoligase; FSF, A subunit; Protein-glutamine gamma-glutamyltransferase A chain; TGase; Transglutaminase A chain; transglutaminase. plasma Specification REACTIVITY: H SENSITIVITY: Endogenous Source/Isotype: Mouse IgG1