CST, 84382S, TMPRSS4 (E5F4W) Rabbit Monoclonal Antibody

Monoclonal Antibody for studying TMPRSS4. Validated for Western Blotting. Available in 2 sizes. Highly specific and rigorously validated in-house, TMPRSS4 (E5F4W) Rabbit Monoclonal Antibody (CST #84382) is ready to ship. Product Usage Information Western Blotting: 1:1000 Storage Supplied in 10 mM sodium HEPES (pH 7.5), 150 mM NaCl, 100 µg/mL BSA, 50% glycerol, and less than 0.02% sodium azide. Store at -20°C. Do not aliquot the antibody. For a carrier free (BSA and azide free) version of this product see product # 38186 . Protocol Available protocols: Western Blotting Specificity / Sensitivity TMPRSS4 (E5F4W) Rabbit Monoclonal Antibody recognizes endogenous levels of total TMPRSS4 protein. Species Reactivity: Human Source / Purification Monoclonal antibody is produced by immunizing animals with a synthetic peptide corresponding to residues near the amino terminus of human TMPRSS4 protein. Background Transmembrane protease serine 4 (TMPRSS4) is a type-II transmembrane glycoprotein that functions as a serine protease. The extracellular region of TMPRSS4 harbors a serine protease catalytic domain and a scavenger receptor domain, which is implicated in lipid binding (1,2). TMPRSS4 activity has been implicated in viral infections through its ability to regulate the proteolytic processing of the influenza virus hemagglutinin protein and SARS-CoV-2 spike protein (3,4). TMPRSS4 is also implicated in cancer cell metastasis through the cleavage of urokinase-type plasminogen activator and activation of intracellular signaling cascades that promote cell migration (5,6). These findings, combined with the observation that TMPRSS4 is overexpressed in multiple types of human solid tumors, have prompted investigation into therapeutically targeting TMPRSS4 protease activity (6-9). Alternate Names CAPH2; Channel-activating protease 2; Membrane-type serine protease 2; MT-SP2; TMPRSS3; TMPRSS4; TMPS4; Transmembrane protease serine 4; transmembrane protease, serine 4; transmembrane serine protease 3; transmembrane serine protease 4; type II membrane serine protease Specification REACTIVITY: H SENSITIVITY: Endogenous MW (kDa): 62, 55 Source/Isotype: Rabbit IgG