CST, 84638S, CDX2 (D11D10) Rabbit Monoclonal Antibody (Alexa Fluor® 555 Conjugate)

Monoclonal Antibody for studying CDX2. Validated for Immunofluorescence (Immunocytochemistry). Highly specific and rigorously validated in-house, CDX2 (D11D10) Rabbit Monoclonal Antibody (Alexa Fluor^® 555 Conjugate) (CST #84638) is ready to ship. Product Usage Information Immunofluorescence (Immunocytochemistry): 1:50 Storage Supplied in PBS (pH 7.2), less than 0.1% sodium azide and 2 mg/ml BSA. Store at 4°C. Do not aliquot the antibody. Protect from light. Do not freeze. Protocol Available protocols: Immunofluorescence (Immunocytochemistry) Specificity / Sensitivity CDX2 (D11D10) Rabbit Monoclonal Antibody (Alexa Fluor Species Reactivity: Human Source / Purification Monoclonal antibody is produced by immunizing animals with a synthetic peptide corresponding to residues near the amino terminus of human CDX2 protein. Background CDX2, a homeobox domain-containing transcription factor, is a master regulator of the trophectoderm, the layer that gives rise to extra-embryonic tissues in mammalian development (1). CDX2 is also involved in intestinal development (2), and gain of expression or loss of expression has been associated with various human malignancies, such as Barrett's esophagus (3) and colorectal cancer (4,5). Mouse embryonic stem cells deficient in CDX2 display limited hematopoietic progenitor development and altered gene expression (6), pointing to a role for CDX2 in gene regulation. CDX2 is also implicated in the aberrant expression of genes in human AML cell lines (7). Alternate Names caudal type homeo box transcription factor 2; caudal type homeobox 2; caudal type homeobox transcription factor 2; Caudal-type homeobox protein 2; CDX-3; CDX2; CDX2/AS; CDX3; Homeobox protein CDX-2; homeobox protein miniCDX2 Specification REACTIVITY: H SENSITIVITY: Endogenous Source/Isotype: Rabbit IgG