CST, 85509T, UBQLN2 (D7R2Z) Rabbit Monoclonal Antibody

Monoclonal Antibody for studying UBQLN2. Validated for Western Blotting,Immunoprecipitation. Available in 2 sizes. Highly specific and rigorously validated in-house, UBQLN2 (D7R2Z) Rabbit Monoclonal Antibody (CST #85509) is ready to ship. Product Usage Information Western Blotting: 1:1000 Immunoprecipitation: 1:100 Storage Supplied in 10 mM sodium HEPES (pH 7.5), 150 mM NaCl, 100 µg/ml BSA, 50% glycerol and less than 0.02% sodium azide. Store at -20°C. Do not aliquot the antibody. Protocol Available protocols: Western Blotting, Immunoprecipitation Specificity / Sensitivity UBQLN2 (D7R2Z) Rabbit Monoclonal Antibody recognizes endogenous levels of total UBQLN2 protein. This antibody does not cross-react with UBQLN1 protein. Species Reactivity: Human, Mouse, Rat, Monkey Source / Purification Monoclonal antibody is produced by immunizing animals with a synthetic peptide corresponding to residues near the amino terminus of human UBQLN2 protein. Background Ubiquilin 2 (UBQLN2) is a broadly expressed member of the ubiquilin family of ubiquitin receptor proteins. UBQLN2 is a type 2 ubiquitin-like (UBL) protein that contains an amino-terminal UBL domain, multiple heat shock chaperonin-binding (STI) motifs, several PXX repeats, and a carboxy-terminal ubiquitin-associated (UBA) domain (1-3). Research studies indicate that the UBL domain of UBQLN2 can interact with proteasome subunits (4). The UBA domain of UBQLN2 can interact with ubiquitinated proteins and the autophagosome and allows UBQLN2 to participate in the ubiquitin-proteasome and autophagy pathways (5-8). Mutations in the PXX repeat region of the corresponding gene are associated with an X-linked form of amyotrophic lateral sclerosis (ALS15) and dementia with reduced penetrance in females (9). Alternate Names ALS15; Chap1; DSK2; DSK2 homolog; FLJ10167; FLJ56541; hPLIC-2; HRIHFB2157; N4BP4; Nedd4 binding protein 4; PLIC-2; PLIC2; Protein linking IAP with cytoskeleton 2; ubiquilin 2; Ubiquilin-2; Ubiquitin-like product Chap1/Dsk2; UBQL2; UBQLN2 Specification REACTIVITY: H M R Mk SENSITIVITY: Endogenous MW (kDa): 70 Source/Isotype: Rabbit IgG