CST, 85679T, CXCL13 (F6A4R) Rabbit Monoclonal Antibody

Monoclonal Antibody for studying CXCL13. Validated for Western Blotting,Immunohistochemistry (Paraffin). Available in 2 sizes. Highly specific and rigorously validated in-house, CXCL13 (F6A4R) Rabbit Monoclonal Antibody (CST #85679) is ready to ship. Product Usage Information Western Blotting: 1:1000 Immunohistochemistry (Paraffin): 1:300 - 1:1200 Storage Supplied in 10 mM sodium HEPES (pH 7.5), 150 mM NaCl, 100 µg/mL BSA, 50% glycerol, and less than 0.02% sodium azide. Store at -20°C. Do not aliquot the antibody. For a carrier free (BSA and azide free) version of this product see product # 17688 . Protocol Available protocols: Western Blotting, Immunohistochemistry (Paraffin) Specificity / Sensitivity CXCL13 (F6A4R) Rabbit Monoclonal Antibody recognizes endogenous levels of total CXCL13 protein. This antibody detects 58 and 75 kDa bands of unknown origin in some cell lines. Species Reactivity: Human Source / Purification Monoclonal antibody is produced by immunizing animals with a synthetic peptide corresponding to residues near the carboxy terminus of human CXCL13 protein. Background C-X-C motif chemokine ligand 13 (CXCL13), also known as B cell-attracting chemokine 1 (BCA-1), is a chemokine expressed primarily by follicular dendritic cells of secondary lymphoid organs such as lymph nodes (LNs), Peyer's patches, and spleen (1,2). CXCL13 is the ligand for CXCR5, and upon binding, the CXCL13/CXCR5 axis is required for B cell activation, migration, and homeostasis (1-4). Dysregulated CXCL13 expression has been associated with autoimmunity, cancer, and infectious diseases, making it a potential therapeutic target (5). Alternate Names Angie; ANGIE2; B cell-attracting chemokine 1; B lymphocyte chemoattractant; B-cell chemoattractant; B-cell-attracting chemokine 1; B-cell-homing chemokine (ligand for Burkitt's lymphoma receptor-1); B-lymphocyte chemoattractant; BCA-1; BCA1; BLC; BLR1L; C-X-C motif chemokine 13; C-X-C motif chemokine ligand 13; chemokine (C-X-C motif) ligand 13; chemokine (C-X-C motif) ligand 13 (B-cell chemoattractant); CXC chemokine BLC; CXCL13; CXL13; SCYB13; small inducible cytokine B subfamily (Cys-X-Cys motif), member 13 (B-cell chemoattractant); Small-inducible cytokine B13 Specification REACTIVITY: H SENSITIVITY: Endogenous MW (kDa): 13 Source/Isotype: Rabbit IgG