CST, 85971S, PLP1 Antibody

Polyclonal Antibody for studying PLP1. Validated for Western Blotting. Highly specific and rigorously validated in-house, PLP1 Antibody (CST #85971) is ready to ship. Product Usage Information Western Blotting: 1:1000 Storage Supplied in 10 mM sodium HEPES (pH 7.5), 150 mM NaCl, 100 µg/ml BSA and 50% glycerol. Store at -20°C. Do not aliquot the antibody Protocol Available protocols: Western Blotting Specificity / Sensitivity PLP1 Antibody recognizes endogenous levels of total PLP1 protein. Species Reactivity: Human, Mouse, Rat Source / Purification Polyclonal antibodies are produced by immunizing animals with a synthetic peptide corresponding to residues near the carboxy terminus of human PLP1 protein. Antibodies are purified by protein A and peptide affinity chromatography. Background Myelin proteolipid protein (PLP1) corresponds to the majority of myelin proteins in the CNS, providing support to axons and modulating the axonal growth (1). DM20 is the result of the alternative splicing of the gene, which is linked to oligodendrocyte differentiation and survival. The imbalance of PLP1/DM20 is linked to Pelizaeus-Merzbacher disease (2,3), including mitochondrial damage (4). In addition, PLP1, but not DM20, can enter the mitochondria and participate in the metabolism of cells (5). Alternate Names GPM6C; HLD1; Lipophilin; major myelin proteolipid protein; MMPL; Myelin proteolipid protein; MYPR; PLP; PLP/DM20; PLP1; PMD; proteolipid protein 1; SPG2 Specification REACTIVITY: H M R SENSITIVITY: Endogenous MW (kDa): 20-30 SOURCE: Rabbit