CST, 86006S, CRELD1 (E1B6T) Rabbit Monoclonal Antibody (Alexa Fluor® 647 Conjugate)

Monoclonal Antibody for studying CRELD1. Validated for Flow Cytometry (Live). Highly specific and rigorously validated in-house, CRELD1 (E1B6T) Rabbit Monoclonal Antibody (Alexa Fluor^® 647 Conjugate) (CST #86006) is ready to ship. Product Usage Information Flow Cytometry (Live): 1:50 Storage Supplied in PBS (pH 7.2), less than 0.1% sodium azide, and 2 mg/mL BSA. Store at 4°C. Do not aliquot the antibody. Protect from light. Do not freeze. Protocol Available protocols: Flow Cytometry (Live) Specificity / Sensitivity CRELD1 (E1B6T) Rabbit Monoclonal Antibody (Alexa Fluor Species Reactivity: Human, Mouse, Rat Source / Purification Monoclonal antibody is produced by immunizing animals with a synthetic peptide corresponding to residues near the carboxy terminus of human CRELD1 protein. Background Cysteine-rich with EGF-like domain protein 1 (CRELD1), also known as cirrin, is a multi-pass membrane protein in the CRELD family of ER-resident proteins (1-3). During embryonic development, CRELD1 is critical to heart development, and mutations in are associated with atrioventricular septal defect 2 (AVSD2), a common cardiovascular malformation (2-4). CRELD1 may also play a role in homeostasis of the immune system, as low CRELD1 expression was found to be associated with reduced T cell numbers in blood (5). Alternate Names AVSD2; CIRRIN; CREL1; CRELD1; cysteine rich with EGF like domains 1; Cysteine-rich with EGF-like domain protein 1; cysteine-rich with EGF-like domains 1; DKFZp566D213; Protein disulfide isomerase CRELD1 Specification REACTIVITY: H M R SENSITIVITY: Endogenous Source/Isotype: Rabbit IgG