CST, 86290S, MACC1 (D2K7V) Rabbit Monoclonal Antibody

Monoclonal Antibody for studying MACC1. Validated for Western Blotting. Available in 2 sizes. Highly specific and rigorously validated in-house, MACC1 (D2K7V) Rabbit Monoclonal Antibody (CST #86290) is ready to ship. Product Usage Information Western Blotting: 1:1000 Storage Supplied in 10 mM sodium HEPES (pH 7.5), 150 mM NaCl, 100 µg/ml BSA, 50% glycerol and less than 0.02% sodium azide. Store at -20°C. Do not aliquot the antibody. Protocol Available protocols: Western Blotting Specificity / Sensitivity MACC1 (D2K7V) Rabbit Monoclonal Antibody recognizes endogenous levels of total MACC1 protein. Species Reactivity: Human Source / Purification Monoclonal antibody is produced by immunizing animals with a synthetic peptide corresponding to residues surrounding Pro442 of human MACC1 protein. Background The gene encoding metastasis-associated in colon cancer-1 (MACC1) was identified based on its overexpression in metastatic colon carcinoma (1), and was later shown to be overexpressed in multiple human cancers, including hepatocellular carcinoma, gastric cancer, head and neck cancer, and breast cancer (2-4). MACC1 regulates HGF/MET and β-catenin signaling, resulting in increased proliferation, migration and invasion, and initiation of the epithelial-mesenchymal transition (EMT) (2). Researchers have shown that MACC1 can be used as a prognostic indicator in solid tumors, and that it has potential as a therapeutic target (5). Alternate Names 7A5; MACC1; MACC1, MET transcriptional regulator; MET transcriptional regulator MACC1; metastasis associated in colon cancer 1; Metastasis-associated in colon cancer protein 1; putative binding protein 7a5; SH3 domain-containing protein 7a5; SH3BP4L Specification REACTIVITY: H SENSITIVITY: Endogenous MW (kDa): 97 Source/Isotype: Rabbit IgG