CST, 86714S, XRCC2 (E7M8Y) Rabbit Monoclonal Antibody

Monoclonal Antibody for studying XRCC2. Validated for Western Blotting,Immunoprecipitation. Available in 2 sizes. Highly specific and rigorously validated in-house, XRCC2 (E7M8Y) Rabbit Monoclonal Antibody (CST #86714) is ready to ship. Product Usage Information Western Blotting: 1:1000 Immunoprecipitation: 1:200 Storage Supplied in 10 mM sodium HEPES (pH 7.5), 150 mM NaCl, 100 µg/mL BSA, 50% glycerol, and less than 0.02% sodium azide. Store at -20°C. Do not aliquot the antibody. Protocol Available protocols: Western Blotting, Immunoprecipitation Specificity / Sensitivity XRCC2 (E7M8Y) Rabbit Monoclonal Antibody recognizes endogenous levels of total XRCC2 protein. By western blot, this antibody detects a 40 kDa band of unknown origin. Species Reactivity: Human Source / Purification Monoclonal antibody is produced by immunizing animals with a synthetic peptide corresponding to residues surrounding Lys267 of human XRCC2 protein. Background XRCC2 (X-ray repair cross-complementing protein 2) is one of five RAD51 paralogs that form two distinct complexes, BCDX2 (RAD51B, RAD51C, RAD51D, and XRCC2) and CX3 (RAD51C and XRCC3) (1). Along with RAD51, these complexes are crucial in the repair of DNA double-strand breaks through homologous recombination (2) and in response to DNA replication stress (3,4). XRCC2 expression and genetic polymorphisms are associated with the risk and prognosis of human cancer (5-10). In non-small cell lung cancer (NSCLC) XRCC2 reduces sensitivity to chemotherapy and radiation treatment (11). Alternate Names DKFZp781P0919; DNA repair protein XRCC2; epididymis secretory sperm binding protein; FANCU; RAD51-like; X-ray repair complementing defective repair in Chinese hamster cells 2; X-ray repair cross complementing 2; X-ray repair cross complementing protein 2; X-ray repair cross-complementing protein 2; X-ray repair, complementing defective, repair in Chinese hamster; XRCC2 Specification REACTIVITY: H SENSITIVITY: Endogenous MW (kDa): 29 Source/Isotype: Rabbit IgG