CST, 87189T, OXR1 (E3D2P) Rabbit Monoclonal Antibody

Monoclonal Antibody for studying OXR1. Validated for Western Blotting,Immunoprecipitation. Available in 2 sizes. Highly specific and rigorously validated in-house, OXR1 (E3D2P) Rabbit Monoclonal Antibody (CST #87189) is ready to ship. Product Usage Information Western Blotting: 1:1000 Immunoprecipitation: 1:50 Storage Supplied in 10 mM sodium HEPES (pH 7.5), 150 mM NaCl, 100 µg/ml BSA, 50% glycerol and less than 0.02% sodium azide. Store at -20°C. Do not aliquot the antibody. Protocol Available protocols: Western Blotting, Immunoprecipitation Specificity / Sensitivity OXR1 (E3D2P) Rabbit Monoclonal Antibody recognizes endogenous levels of total OXR1 protein. Based on the sequence of the antigenic peptide, this antibody is expected to detect isoforms 1, 2, 3, 5, and 8 of OXR1. Species Reactivity: Human Source / Purification Monoclonal antibody is produced by immunizing animals with a synthetic peptide corresponding to residues surrounding Val180 of human OXR1 protein. Background Oxidation resistance 1 (OXR1) protein is a cellular oxidative stress sensor that regulates expression of signaling proteins involved in cell cycle arrest and apoptosis (1). Depletion of OXR1 plays a role in oxidative stress associated with neurodegenerative diseases, including Parkinson's disease, diabetic retinopathy, hyperoxia induced retinopathy, and neuronal damage (2). OXR1 also plays a role in cell cycle arrest in response to DNA damage (3,4), and is upregulated in cells undergoing senescence (5). OXR1 is a target of the senolytic agent, piperlongumine, and its analogues (5). Alternate Names CHEGDD; FLJ10125; FLJ38829; FLJ41673; FLJ42450; FLJ45656; Nbla00307; oxidation resistance 1; Oxidation resistance protein 1; OXR1; putative protein product of Nbla00307; TBC/LysM-associated domain containing 3; TLDC3 Specification REACTIVITY: H SENSITIVITY: Endogenous MW (kDa): 139 Source/Isotype: Rabbit IgG