CST, 88246T, Phospho-Synapsin-1 (Ser605) (D4B9I) Rabbit Monoclonal Antibody

Monoclonal Antibody for studying Synapsin-1 (Ser605) phosphate. Validated for Western Blotting. Available in 2 sizes. Highly specific and rigorously validated in-house, Phospho-Synapsin-1 (Ser605) (D4B9I) Rabbit Monoclonal Antibody (CST #88246) is ready to ship. Product Usage Information Western Blotting: 1:1000 Storage Supplied in 10 mM sodium HEPES (pH 7.5), 150 mM NaCl, 100 µg/ml BSA, 50% glycerol and less than 0.02% sodium azide. Store at -20°C. Do not aliquot the antibody. Protocol Available protocols: Western Blotting Specificity / Sensitivity Phospho-Synapsin-1 (Ser605) (D4B9I) Rabbit Monoclonal Antibody recognizes endogenous levels of Synapsin-1 protein only when phosphorylated at Ser605 (corresponds to Ser603 in rat). Species Reactivity: Human, Mouse, Rat Source / Purification Monoclonal antibody is produced by immunizing animals with a synthetic peptide corresponding to residues surrounding Ser605 of human Synapsin-1 protein. Background Synapsins, a group of at least five related members (synapsins Ia, Ib, IIa, IIb, and IIIa), are abundant brain proteins essential for regulating neurotransmitter release (1,2). All synapsins contain a short amino-terminal domain that is highly conserved and phosphorylated by PKA or CaM kinase I (1). Phosphorylation of the synapsin amino-terminal domain at Ser9 inhibits its binding to phospholipids and dissociates synapsins from synaptic vesicles (2). Alternate Names Brain protein 4.1; MRX50; SYN1; SYN1a; SYN1b; Synapsin; Synapsin I; synapsin Ib; Synapsin-1; SYNI Specification REACTIVITY: H M R SENSITIVITY: Endogenous MW (kDa): 75-90 Source/Isotype: Rabbit IgG