CST, 88464T, LAMA2 (F4S9K) Rabbit Monoclonal Antibody

Monoclonal Antibody for studying LAMA2. Validated for Western Blotting,Immunofluorescence (Frozen). Available in 2 sizes. Highly specific and rigorously validated in-house, LAMA2 (F4S9K) Rabbit Monoclonal Antibody (CST #88464) is ready to ship. Product Usage Information Western Blotting: 1:1000 Immunofluorescence (Frozen): 1:100 Storage Supplied in 10 mM sodium HEPES (pH 7.5), 150 mM NaCl, 100 µg/mL BSA, 50% glycerol, and less than 0.02% sodium azide. Store at -20°C. Do not aliquot the antibody. Protocol Available protocols: Western Blotting, Immunofluorescence (Frozen) Specificity / Sensitivity LAMA2 (F4S9K) Rabbit Monoclonal Antibody recognizes endogenous levels of total LAMA2 protein. Species Reactivity: Human, Mouse, Rat Source / Purification Monoclonal antibody is produced by immunizing animals with a synthetic peptide corresponding to residues surrounding Pro1215 of human LAMA2 protein. Background Laminins are a family of proteins important for maintaining the cellular basement membrane (BM) structure and function (1). Laminins exist as heterotrimers of alpha (LAMA), beta (LAMB), and gamma (LAMC) chains. Laminins are reported to be involved in multiple biological processes, including cell adhesion, differentiation, migration, signaling, neurite outgrowth, and metastasis (2). LAMA2 is thought to be associated with the development and function of oligodendrocytes, the cortical plate, and the blood-brain barrier during embryonic and postnatal development. Aberrant expression of LAMA2 is associated with disease progression in patients with congenital muscular dystrophy type 1A (MDC1A) (3). Alternate Names LAMA2; Laminin M chain; laminin subunit alpha 2; Laminin subunit alpha-2; Laminin-12 subunit alpha; Laminin-2 subunit alpha; Laminin-4 subunit alpha; laminin, alpha 2; LAMM; MDC1A; Merosin heavy chain; mutant laminin subunit alpha 2 Specification REACTIVITY: H M R SENSITIVITY: Endogenous MW (kDa): 344 Source/Isotype: Rabbit IgG