CST, 88513S, IL-33 (E2T5L) Rabbit Monoclonal Antibody

Monoclonal Antibody for studying IL33. Validated for Western Blotting. Available in 2 sizes. Highly specific and rigorously validated in-house, IL-33 (E2T5L) Rabbit Monoclonal Antibody (CST #88513) is ready to ship. Product Usage Information Western Blotting: 1:1000 Storage Supplied in 10 mM sodium HEPES (pH 7.5), 150 mM NaCl, 100 µg/ml BSA, 50% glycerol and less than 0.02% sodium azide. Store at -20°C. Do not aliquot the antibody. Protocol Available protocols: Western Blotting Specificity / Sensitivity IL-33 (E2T5L) Rabbit Monoclonal Antibody recognizes endogenous levels of total IL-33 protein. Species Reactivity: Human Source / Purification Monoclonal antibody is produced by immunizing animals with human IL-33 recombinant protein and reacts with an epitope surrounding Glu165. Background IL-33 (Interleukin-33, NF-HEV) is a nuclear cytokine that is part of the IL-1 family (1,2). Originally discovered as the ‘nuclear factor from high endothelial venules,' it is widely expressed by endothelial cells as well as epithelial barrier tissues (1,5). IL-33 is involved in regulating type 2-associated innate immune responses (2,4). It is the ligand for ST2 which, along with IL-1RAcP, forms the IL-33R signaling complex (2,3). IL-33 functions as an alarmin upon cellular damage or stress, and is associated with allergic inflammation and asthma (5,6). Alternate Names C9orf26; DKFZp586H0523; DVS27; DVS27-related protein; IL-1F11; IL-33; IL1F11; IL33; interleukin 33; Interleukin-1 family member 11; Interleukin-33; Interleukin-33 (109-270); Interleukin-33 (95-270); Interleukin-33 (99-270); NF-HEV; NFEHEV; NFHEV; nuclear factor for high endothelial venules; Nuclear factor from high endothelial venules; RP11-575C20.2 Specification REACTIVITY: H SENSITIVITY: Endogenous MW (kDa): 30 Source/Isotype: Rabbit IgG