CST, 89262S, TBK1/NAK (E8I3G) Rabbit Monoclonal Antibody (InTraSeq™ 3' Conjugate 3091)

Monoclonal Antibody for studying TBK1. Validated for Single Cell Analysis - InTraSeq™ 3'. Highly specific and rigorously validated in-house, TBK1/NAK (E8I3G) Rabbit Monoclonal Antibody (InTraSeq^™ 3' Conjugate 3091) (CST #89262) is ready to ship. Storage Supplied in PBS (pH 7.2), 2 mM EDTA, 0.05% Triton X-100, 2 mg/mL BSA, and 50% glycerol. Store at -20°C. Do not aliquot the antibody . Protocol Available protocols: Single Cell Analysis - InTraSeq™ 3' Specificity / Sensitivity TBK1/NAK (E8I3G) Rabbit mAb (InTraSeq™ 3' Conjugate 3091) recognizes endogenous levels of total TBK1/NAK protein. Species Reactivity: Human, Mouse Source / Purification Monoclonal antibody is produced by immunizing animals with a synthetic peptide corresponding to residues near the carboxy terminus of human TBK1/NAK protein. Background TBK1 (TANK-binding kinase 1)/NAK (NF-κB activating kinase) is an IκB kinase (IKK)-activating kinase and can activate IKK through direct phosphorylation (1). TBK1 was identified through association with the TRAF binding protein, TANK, and found to function upstream of NIK and IKK in the activation of NF-κB (2). TBK1 induces IκB degradation and NF-κB activity through IKKβ. TBK1 may mediate IKK and NF-κB activation in response to growth factors that stimulate PKCε activity (1). TBK1 plays a pivotal role in the activation of IRF3 in the innate immune response (3). Alternate Names FLJ11330; FTDALS4; IIAE8; NAK; NF-kappa-B-activating kinase; NF-kB-activating kinase; Serine/threonine-protein kinase TBK1; T2K; TANK binding kinase 1; TANK-binding kinase 1; TBK1 Specification REACTIVITY: H M SENSITIVITY: Endogenous Source/Isotype: Rabbit IgG