CST, 89326S, UCP2 (D1O5V) Rabbit Monoclonal Antibody

Monoclonal Antibody for studying UCP2. Validated for Western Blotting. Available in 2 sizes. Highly specific and rigorously validated in-house, UCP2 (D1O5V) Rabbit Monoclonal Antibody (CST #89326) is ready to ship. Product Usage Information Western Blotting: 1:1000 Storage Supplied in 10 mM sodium HEPES (pH 7.5), 150 mM NaCl, 100 µg/ml BSA, 50% glycerol and less than 0.02% sodium azide. Store at -20°C. Do not aliquot the antibody. Protocol Available protocols: Western Blotting Specificity / Sensitivity UCP2 (D1O5V) Rabbit Monoclonal Antibody recognizes endogenous levels of total UCP2 protein. Species Reactivity: Human, Mouse, Rat, Monkey Source / Purification Monoclonal antibody is produced by immunizing animals with a synthetic peptide corresponding to residues surrounding Gly153 of human UCP2 protein. Background Uncoupling protein 2 (UCP2) is a mitochondrial inner membrane transport protein that is expressed in a wide range of tissues (1). UCP2 inhibits mitochondrial glucose oxidation and promotes glycolysis in human pluripotent stem cells (hPSCs) (2). During early differentiation of hPSCs, the expression of UCP2 is repressed, which results in reduced glycolysis (2). This demonstrates a role for UCP2 in the metabolic reprogramming during differentiation of hPSCs (2). Overexpression of UCP2 in cancer cells stimulates oxidative phosphorylation in mitochondria and inhibits cell proliferation (3). Alternate Names BMIQ4; Dicarboxylate carrier SLC25A8; Mitochondrial uncoupling protein 2; SLC25A8; Solute carrier family 25 member 8; UCP 2; UCP2; UCPH; uncoupling protein 2; uncoupling protein 2 (mitochondrial, proton carrier) Specification REACTIVITY: H M R Mk SENSITIVITY: Endogenous MW (kDa): 32 Source/Isotype: Rabbit IgG