CST, 89844S, ATAD3A (F6S8N) Rabbit Monoclonal Antibody

Monoclonal Antibody for studying ATAD3A. Validated for Western Blotting,Immunohistochemistry (Paraffin). Available in 2 sizes. Highly specific and rigorously validated in-house, ATAD3A (F6S8N) Rabbit Monoclonal Antibody (CST #89844) is ready to ship. Product Usage Information Western Blotting: 1:1000 Immunohistochemistry (Paraffin): 1:20000 Storage Supplied in 10 mM sodium HEPES (pH 7.5), 150 mM NaCl, 100 µg/mL BSA, 50% glycerol, and less than 0.02% sodium azide. Store at -20°C. Do not aliquot the antibody. Protocol Available protocols: Western Blotting, Immunohistochemistry (Paraffin) Specificity / Sensitivity ATAD3A (F6S8N) Rabbit Monoclonal Antibody recognizes endogenous levels of total ATAD3A protein. Species Reactivity: Human Source / Purification Monoclonal antibody is produced by immunizing animals with a synthetic peptide corresponding to residues near the carboxy terminus of human ATAD3A protein. Background ATPase family AAA domain-containing protein 3 (ATAD3) is a mitochondrial AAA+ ATPase protein localized between the inner and outer mitochondrial membrane (1). ATAD3 interacts with several inner mitochondrial membrane proteins, and its role includes stabilizing mitochondrial DNA, regulating mitochondrial fission/fusion, and regulating cholesterol homeostasis (2,3). ATAD3 has three paralogs, ATAD3A, ATAD3B, and ATAD3C. ATAD3B acts as a negative regulator of ATAD3A (4). Numerous mutations have been identified in patients with neurological diseases and neurodegenerative diseases, such as Huntington's disease and Alzheimer's disease. These mutations are distributed throughout different protein domains, resulting in dysfunctional ATAD3A (3-5). Alternate Names ATAD3A; ATD3A; ATPase family AAA domain containing 3A; ATPase family AAA domain-containing protein 3A; ATPase family, AAA domain containing 3A; FLJ10709; FLJ35514; HAYOS; PHRINL Specification REACTIVITY: H SENSITIVITY: Endogenous MW (kDa): 71 Source/Isotype: Rabbit IgG