CST, 90963S, Neurexin-3 Antibody

Polyclonal Antibody for studying NRXN3. Validated for Western Blotting. Highly specific and rigorously validated in-house, Neurexin-3 Antibody (CST #90963) is ready to ship. Product Usage Information Western Blotting: 1:1000 Storage Supplied in 10 mM sodium HEPES (pH 7.5), 150 mM NaCl, 100 µg/ml BSA and 50% glycerol. Store at -20°C. Do not aliquot the antibody. Protocol Available protocols: Western Blotting Specificity / Sensitivity Neurexin-3 Antibody recognizes endogenous levels of total Neurexin-3 protein. Species Reactivity: Human, Mouse, Rat Source / Purification Polyclonal antibodies are produced by immunizing animals with a synthetic peptide corresponding to residues surrounding Met629 of human Neurexin-3 protein. Antibodies are purified by peptide affinity chromatography. Background Neurexins are a highly polymorphic cell surface protein family, containing single transmembrane regions and extracellular domains with repeated sequences similar to laminin A, slit, and agrin, proteins that are implicated in axon guidance and synaptogenesis (1,2). The family includes Neurexin-1, -2, and -3 (NRXN1, NRXN2, and NRXN3). Each member of the Neurexin family undergoes alternative splicing, resulting in α- and β-forms of Neurexin. α-neurexins contain six laminin/neurexin/sex (LNS)-hormone-binding globulin domains. β-neurexins are transcribed from an internal promoter of their respective genes. They are composed of an N-terminal β-neurexin-specific sequence that splices into the α-neurexin sequence LNS6 domain N-terminal, generating what is effectively an N-terminally truncated α-neurexin with a short N-terminal β-neurexin motif. γ-neurexins are only transcribed from the gene and splice into the α and 1β sequence of what encodes the LNS6 domain C-terminal (3). Alternate Names C14orf60; KIAA0743; MGC176711; neurexin 3; neurexin III; Neurexin III-alpha; neurexin III-beta; Neurexin-3; Neurexin-3-alpha; neurexin-3-beta; NRX3A; NRXN3 Specification REACTIVITY: H M R SENSITIVITY: Endogenous MW (kDa): 180 SOURCE: Rabbit