CST, 91322T, Pan-Keratin (C11) Mouse Monoclonal Antibody (Alexa Fluor® 750 Conjugate)

Monoclonal Antibody for studying K6c/K10/KRT6B/K8/K13/K6a/KRT18/K5/K4. Validated for Immunohistochemistry (Paraffin),Flow Cytometry (Fixed/Permeabilized). Available in 2 sizes. Highly specific and rigorously validated in-house, Pan-Keratin (C11) Mouse Monoclonal Antibody (Alexa Fluor^® 750 Conjugate) (CST #91322) is ready to ship. Product Usage Information Immunohistochemistry (Paraffin): 1:50 - 1:200 Flow Cytometry (Fixed/Permeabilized): 1:200 Storage Supplied in PBS (pH 7.2), less than 0.1% sodium azide, and 2 mg/mL BSA. Store at 4°C. Do not aliquot the antibody. Protect from light. Do not freeze. Protocol Available protocols: Immunohistochemistry (Paraffin), Flow Cytometry (Fixed/Permeabilized) Specificity / Sensitivity Pan-Keratin (C11) Mouse Monoclonal Antibody (Alexa Fluor Species Reactivity: Human, Mouse, Rat, Monkey Source / Purification Monoclonal antibody (isotype: IgG1) is produced by immunizing a BALB/c mouse with a cytoskeleton preparation from A-431 cells. Background KHSRP, also known as KSRP, is a KH domain-containing AU-rich element (ARE) binding protein (1). It recruits degradation machinery and activates mRNA turnover (2). This protein was previously shown to function as a regulator for splicing (3). KHSRP associates with both the Drosha and Dicer multiprotein complexes (4), and controls the biogenesis of some microRNAs by binding to the terminal loops of these microRNA precursors (3). KHSRP is found in neural and non-neural cell types in both the nucleus and the cytoplasm (4). Alternate Names 56 cytoskeletal type II keratin; 58 kDa cytokeratin; BCIE; BIE; CARD2; Cell proliferation-inducing gene 46 protein; cell proliferation-inducing protein 46; CK-10; CK-13; CK-18; CK-4; CK-5; CK-6A; CK-6B; CK-6C; CK-6D; CK-6E; CK-8; CK10; CK13; CK4; CK5; CK6A; CK6B; CK6C; CK6D; CK8; CYK18; CYK4; CYK8; cytokeratin 10; cytokeratin 13; cytokeratin 18; cytokeratin 4; cytokeratin 6A; cytokeratin 6B; cytokeratin 6C; cytokeratin 6D; cytokeratin 8; Cytokeratin-10; Cytokeratin-13; Cytokeratin-18; Cytokeratin-4; Cytokeratin-5; Cytokeratin-6A; Cytokeratin-6B; Cytokeratin-6C; Cytokeratin-6D; Cytokeratin-6E; Cytokeratin-8; DDD; DDD1; EBS2; EHK; epidermolysis bullosa simplex 2 Dowling-Meara/Kobner/Weber-Cockayne types; FLJ31692; K10; K13; K18; K1C10; K1C13; K1C18; K2C4; K2C5; K2C6A; K2C6B; K2C6C; K2C8; K4; K5; K6A; K6B; K6C; K6D; K6D keratin; K6E; K8; keratin 10; keratin 10, type I; keratin 13; keratin 13, type I; keratin 18; keratin 18, type I; keratin 4; keratin 4, type II; keratin 5; keratin 5 (epidermolysis bullosa simplex, Dowling-Meara/Kobner/Weber-Cockayne types); keratin 5, type II; Keratin 6; keratin 6A; keratin 6A, , type II; keratin 6A, type II; keratin 6B; keratin 6B, type II; keratin 6C; keratin 6C, type II; keratin 6E; keratin 8; keratin 8, type II; Keratin K6h; Keratin-10; Keratin-13; Keratin-18; Keratin-4; Keratin-5; Keratin-6A; Keratin-6B; Keratin-6C; Keratin-8; keratin-like 1 (a type II keratin sequence); keratin, epidermal type II, K6A; keratin, epidermal type II, K6C; keratin, epidermal, type II, K6B; Keratin, type I cytoskeletal 10; Keratin, type I cytoskeletal 13; Keratin, type I cytoskeletal 18; Keratin, type II cytoskeletal 4; Keratin, type II cytoskeletal 5; Keratin, type II cytoskeletal 6A; Keratin, type II cytoskeletal 6B; Keratin, type II cytoskeletal 6C; keratin, type II cytoskeletal 6D; Keratin, type II cytoskeletal 8; KO; KPP; KRT10; KRT13; KRT18; KRT4; KRT5; KRT5A; KRT6A; KRT6B; KRT6C; KRT6D; KRT6E; KRT8; KRTL1; MGC102925; MGC161462; MGC163455; MGC163457; MGC3781; PC2; PC3; PC4; PPKNEFD; type II keratin isoform K6c; Type-II keratin Kb10; Type-II keratin Kb12; Type-II keratin Kb4; Type-II keratin Kb5; Type-II keratin Kb6; Type-II keratin Kb8; WSN1; WSN2 Specification REACTIVITY: H M R Mk SENSITIVITY: Endogenous Source/Isotype: Mouse IgG1