CST, 92574T, TRIM46 (E4X9J) Rabbit Monoclonal Antibody

Monoclonal Antibody for studying TRIM46 mouse. Validated for Western Blotting,Immunofluorescence (Frozen). Available in 2 sizes. Highly specific and rigorously validated in-house, TRIM46 (E4X9J) Rabbit Monoclonal Antibody (CST #92574) is ready to ship. Product Usage Information Western Blotting: 1:1000 Immunofluorescence (Frozen): 1:200 - 1:400 Storage Supplied in 10 mM sodium HEPES (pH 7.5), 150 mM NaCl, 100 µg/mL BSA, 50% glycerol, and less than 0.02% sodium azide. Store at -20°C. Do not aliquot the antibody. Protocol Available protocols: Western Blotting, Immunofluorescence (Frozen) Specificity / Sensitivity TRIM46 (E4X9J) Rabbit Monoclonal Antibody recognizes endogenous levels of total TRIM46 protein. Species Reactivity: Human, Mouse, Rat Source / Purification Monoclonal antibody is produced by immunizing animals with a synthetic peptide corresponding to residues near the carboxy terminus of human TRIM46 protein. Background Tripartite motif-containing protein 46 (TRIM46), a member of the tripartite motif (TRIM)-containing protein family, was initially identified as the oncogene in several human tumors (1). Since, it has been further characterized as a microtubule-associated protein involved in the formation of parallel microtubule bundles linked by cross-bridges in the proximal axon during the initial polarization of neuronal cells (2). TRIM46 has an essential role in organizing microtubule fascicles in the axon initial segment. Thereby it is required for proper axon Specification, the establishment of neuronal polarity, and proper neuronal migration (3). Alternate Names AI385631; Gene Y protein; GeneY; MGC90834; OTTMUSP00000024715; OTTMUSP00000024716; TRI; TRI46; Trific; Trim46; tripartite motif protein 46; tripartite motif-containing 46; Tripartite motif-containing protein 46; tripartite, fibronectin type III and C-terminal SPRY motif-containing; Tripartite, fibronectin type-III and C-terminal SPRY motif protein Specification REACTIVITY: H M R SENSITIVITY: Endogenous MW (kDa): 82 Source/Isotype: Rabbit IgG