CST, 92948S, TNFRSF13C/BAFF-R Antibody

Polyclonal Antibody for studying BAFF-R. Validated for Western Blotting,Immunoprecipitation. Highly specific and rigorously validated in-house, TNFRSF13C/BAFF-R Antibody (CST #92948) is ready to ship. Product Usage Information Western Blotting: 1:1000 Immunoprecipitation: 1:50 Storage Supplied in 10 mM sodium HEPES (pH 7.5), 150 mM NaCl, 100 µg/ml BSA and 50% glycerol. Store at -20°C. Do not aliquot the antibody. Protocol Available protocols: Western Blotting, Immunoprecipitation Specificity / Sensitivity TNFRSF13C/BAFF-R Antibody recognizes endogenous levels of total TNFRSF13C/BAFF-R protein. This antibody also cross-reacts with an unidentified protein of 19 kDa in some cell extracts. Species Reactivity: Human Source / Purification Polyclonal antibodies are produced by immunizing animals with a synthetic peptide corresponding to residues near the carboxy terminus of human TNFRSF13C/BAFF-R protein. Antibodies are purified by peptide affinity chromatography. Background B cell-activating factor (BAFF)-receptor (BAFF-R) is a type III transmembrane protein that is expressed almost exclusively on the surface of normal, mature B cells as well as malignant B cells from various forms of B cell lymphoproliferative disorders (1). Unlike BCMA and TACI, BAFF-R only binds BAFF and this interaction plays a fundamental role in driving B cell survival and proliferation by engaging canonical and non-canonical NF-κB signaling modules (2-4). Because its expression is largely restricted to the B cell lineage, BAFF-R is being investigated as an additional immunotherapeutic target for B cell malignancies (5,6). Alternate Names B cell-activating factor receptor; B-cell-activating factor receptor; BAFF receptor; BAFF-R; BAFFR; BLyS receptor 3; BR3; BROMIX; CD268; CVID4; MGC138235; prolixin; TNF receptor superfamily member 13C; TNFRSF13C; TR13C; Tumor necrosis factor receptor superfamily member 13C; tumor necrosis factor receptor superfamily, member 13C Specification REACTIVITY: H SENSITIVITY: Endogenous MW (kDa): 38, 50 SOURCE: Rabbit