CST, 93019S, STRN (E9V5M) Rabbit Monoclonal Antibody

Monoclonal Antibody for studying STRN. Validated for Western Blotting,Immunoprecipitation. Available in 2 sizes. Highly specific and rigorously validated in-house, STRN (E9V5M) Rabbit Monoclonal Antibody (CST #93019) is ready to ship. Product Usage Information Western Blotting: 1:1000 Immunoprecipitation: 1:100 Storage Supplied in 10 mM sodium HEPES (pH 7.5), 150 mM NaCl, 100 µg/mL BSA, 50% glycerol, and less than 0.02% sodium azide. Store at -20°C. Do not aliquot the antibody. Protocol Available protocols: Western Blotting, Immunoprecipitation Specificity / Sensitivity STRN (E9V5M) Rabbit Monoclonal Antibody recognizes endogenous levels of total STRN protein. Species Reactivity: Human, Mouse Source / Purification Monoclonal antibody is produced by immunizing animals with a synthetic peptide corresponding to residues surrounding Pro273 of human STRN protein. Background The mammalian striatin family consists of three proteins: Striatin (STRN), Striatin S/G2 nuclear autoantigen (STRN3), and Zinedin (STRN4). It is a component of STRIPAK complexes that function as a scaffold in various signaling pathways (1). The multi-protein STRIPAK complexes play important roles in various biological processes associated with signal transduction pathways, cell division, differentiation, and survival. These complexes have also been linked to several pathological conditions, including cancer, heart disease, diabetes, and neurological diseases. One of the major functions of STRIPAK complexes is to anchor and regulate protein phosphatase 2A (PP2A) activity (2). Phosphorylation of Striatin by ULK1 promotes activation of PP2A and autophagy (3). Striatin is predominantly found in the central and peripheral nervous systems, but its expression can be found in other tissues (4,5). Downregulation of Striatin in motor neurons impaired dendritic growth (6). The gene has been identified as a rare fusion partner with tyrosine kinases and observed in several cancers (7-9). Alternate Names MGC125642; PPP2R6A; protein phosphatase 2 regulatory subunit B'''alpha; SG2NA; Striatin; striatin, calmodulin binding protein; striatin, calmodulin-binding protein; STRN; STRN1 Specification REACTIVITY: H M SENSITIVITY: Endogenous MW (kDa): 105 Source/Isotype: Rabbit IgG