CST, 93584S, ABT-737

Chemical Modulators for studying in the research area. Product Usage Information ABT-737 is supplied as a lyophilized powder. For a 10 mM stock, reconstitute 5 mg of powder in 615 μL of DMSO. Working concentrations and length of treatment can vary depending on the desired effect. Storage Store lyophilized at -20ºC, desiccated. In lyophilized form, the chemical is stable for 24 months. Once in solution, store at -20ºC and use within 3 months to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles. Background ABT-737 is a BH3 mimetic that is a potent inhibitor of multiple Bcl-2 family members, including Bcl-xL, Bcl-2, and Bcl-w that all have a Ki value of less than or equal to 1 nM (1,3). ABT-737 binds to these anti-apoptotic Bcl-2 family members and inhibits their interaction with pro-apoptotic BH3-domain proteins, leading to Bax-Bak mediated apoptosis. ABT-737 has cytotoxic activity in multiple cancer types, including small-cell lung cancer and lymphoid malignancies (2,3). It has also been shown to inhibit and regress tumor growth in xenograft tumor mouse models (3). Alternate Names 4-[4-[(4'-Chloro[1,1'-biphenyl]-2-yl)methyl]-1-piperazinyl]-N-[[4-[[(1R)-3-(dimethylamino)-1- [(phenylthio)methyl]propyl]amino]-3-nitrophenyl]sulfonyl]-benzamide