CST, 93782S, GPR37L1 (D8F5Q) Rabbit Monoclonal Antibody

Monoclonal Antibody for studying GPR37L1. Validated for Western Blotting. Available in 2 sizes. Highly specific and rigorously validated in-house, GPR37L1 (D8F5Q) Rabbit Monoclonal Antibody (CST #93782) is ready to ship. Product Usage Information Western Blotting: 1:1000 Storage Supplied in 10 mM sodium HEPES (pH 7.5), 150 mM NaCl, 100 µg/ml BSA, 50% glycerol and less than 0.02% sodium azide. Store at -20°C. Do not aliquot the antibody. Protocol Available protocols: Western Blotting Specificity / Sensitivity GPR37L1 (D8F5Q) Rabbit Monoclonal Antibody recognizes endogenous levels of total GPR37L1 protein. Species Reactivity: Human Source / Purification Monoclonal antibody is produced by immunizing animals with a synthetic peptide corresponding to residues surrounding Ala53 of human GPR37L1 protein. Background GPR37-like receptor (GPR37L1), also known as endothelin B receptor-like protein 2 (ETBR-LP-2) and GPCR/CNS2, is an orphan G protein coupled-receptor (1,2,3). GPR37L1 and its closely related receptor, GPR37, are endothelin receptor-like GPCRs that are highly expressed in the central nervous system. GPR37L1 is broadly expressed in the brain and regulates multiple neuronal functions, including cerebellar development (4). Studies also indicate that GPR37L1 and GPR37 may be receptors for prosaposin and prosaptide. Peptide-dependent modulation of GPR37L1 activity may regulate neuronal and glial survival, as prosaposin is known to exert neuroprotective, neurotrophic, and gliotrophic actions. (5,6). Alternate Names Endothelin B receptor-like protein 2; endothelin type b receptor-like protein 2; ET(B)R-LP-2; ETBR-LP-2; ETBR2; ETBRLP2; G protein-coupled receptor 37 like 1; G-protein coupled receptor 37 like 1; G-protein coupled receptor 37-like 1; G37L1; GPR37L1; Prosaposin receptor GPR37L1 Specification REACTIVITY: H SENSITIVITY: Endogenous MW (kDa): 48 Source/Isotype: Rabbit IgG