CST, 94097C, PathScan® RP BDNF Sandwich ELISA Kit

ELISA Kit for studying BDNF in the research area. Protocol Available protocols: ELISA+ Specificity / Sensitivity The PathScan Species Reactivity: Human, Mouse Background Neurotrophins are composed of at least four family members, including NGF, BDNF, NT-3, and NT-4, and all are known to influence growth, development, differentiation, and survival of neurons (1). Proneurotrophins bind to p75NTR, but not to the family of Trk receptor tyrosine kinases (Trk), and following maturation, BDNF binds and activates TrkB. Trk receptors, in turn, activate three major signaling pathways: (a) Ras-MAPK signaling, which promotes neuronal differentiation and neurite outgrowth, (b) PI3K/Akt signaling, which promotes survival and growth of neurons, and (c) PLC-γ1-PKC signaling, which promotes synaptic plasticity (2). BDNF is a major regulator of transmission and plasticity at adult synapses. Moreover, the precursor proBDNF and the mature protein mBDNF drive opposite effects on long-term potentiation and long-term depression (3). BDNF has also been implicated in body weight regulation and activity: heterozygous BDNF knockout mice are hyperphagic, obese, and hyperactive (4). Alternate Names Abrineurin; ANON2; BDNF; BDNF precursor form; brain derived neurotrophic factor; Brain-derived neurotrophic factor; BULN2; MGC34632; neurotrophin; ProBDNF Specification REACTIVITY: H M