CST, 94277S, INSM1 (F7P8K) Rabbit Monoclonal Antibody

Monoclonal Antibody for studying INSM1. Validated for Western Blotting,Simple Western™. Available in 2 sizes. Highly specific and rigorously validated in-house, INSM1 (F7P8K) Rabbit Monoclonal Antibody (CST #94277) is ready to ship. Product Usage Information Western Blotting: 1:1000 Simple Western™: 1:10 - 1:50 Storage Supplied in 10 mM sodium HEPES (pH 7.5), 150 mM NaCl, 100 µg/mL BSA, 50% glycerol, and less than 0.02% sodium azide. Store at -20°C. Do not aliquot the antibody. Protocol Available protocols: Western Blotting Specificity / Sensitivity INSM1 (F7P8K) Rabbit Monoclonal Antibody recognizes endogenous levels of total INSM1 protein. Species Reactivity: Human Source / Purification Monoclonal antibody is produced by immunizing animals with recombinant protein specific to the carboxy terminus of human INSM1 protein. Background Insulinoma-associated protein 1 (INSM1), originally named IA-1, is a zinc-finger protein cloned from an insulinoma and glucagonoma subtraction library (1). It is a transcriptional repressor expressed in the developing pancreas and nervous system and targets genes such as β and insulin, critical regulators of neuroendocrine differentiation during development (2-5). Most importantly, INSM1 has emerged as a key marker in neuroendocrine tumor types, including small cell lung cancer (SCLC), medullary thyroid carcinoma, pheochromocytoma, Merkel cell carcinoma, neuroblastoma, and neuroendocrine tumors of the pancreas, breast, colon, bladder, and prostate (6-9). Some studies have also shown that the level of INSM1 expression may have prognostic value (10,11). Alternate Names IA-1; IA1; INSM transcriptional repressor 1; INSM1; insulinoma-associated 1; Insulinoma-associated protein 1; Zinc finger protein IA-1 Specification REACTIVITY: H SENSITIVITY: Endogenous MW (kDa): 63 Source/Isotype: Rabbit IgG