CST, 95835S, CD103/ITGAE (EP206) Rabbit Monoclonal Antibody

Monoclonal Antibody for studying CD103. Validated for IHC Leica Bond,Immunohistochemistry (Paraffin). Available in 2 sizes. Highly specific and rigorously validated in-house, CD103/ITGAE (EP206) Rabbit Monoclonal Antibody (CST #95835) is ready to ship. Product Usage Information IHC Leica Bond: 1:50 - 1:200 Immunohistochemistry (Paraffin): 1:50 - 1:200 Storage Supplied in a Tris-based buffer with ~1% BSA and less than 0.1% sodium azide. Stable for 12 months when stored at 4°C. Do not aliquot the antibody. Note: This product is only available in the format listed above. We are unable to provide this in a carrier free, custom formulation. Protocol Available protocols: IHC Leica Bond, Immunohistochemistry (Paraffin) Specificity / Sensitivity CD103/ITGAE (EP206) Rabbit Monoclonal Antibody recognizes endogenous levels of CD103/ITGAE protein. Non-specific staining was observed in kidney proximal tubules by immunohistochemistry. Species Reactivity: Human Source / Purification Monoclonal antibody is produced by immunizing animals with a synthetic peptide corresponding to the residues of human CD103/ITGAE protein. Background Cluster of differentiation molecule 103 (CD103)/Integrin, alpha E (ITGAE) is a transmembrane protein forming heterodimers that are composed of α and β subunits. CD103/ITGAE is expressed by subsets of CD4 and CD8 T cells, dendritic cells, and mast cells in mucosal tissues (1,2). The heterodimer composed of CD103/ITGAE and integrin beta 7 interacts with E-cadherin, a cellular adhesion molecule found on epithelial cells. The CD103/ITGAE and integrin beta 7 complex plays a role in thymocyte proliferation, intestinal T cell homing, and the antitumor immune response (3-5). Studies have shown that the presence of CD103/ITGAE(+) immune cells can be used as markers for a favorable prognosis in different epithelial cancers (6,7). Alternate Names alpha polypeptide; alpha polypeptide); antigen CD103, human mucosal lymphocyte antigen 1; CD103; HML-1 antigen; human mucosal lymphocyte antigen 1, alpha polypeptide; HUMINAE; Integrin alpha-E; Integrin alpha-E heavy chain; Integrin alpha-E light chain; Integrin alpha-IEL; integrin subunit alpha E; integrin, alpha E (antigen CD103, human mucosal lymphocyte antigen 1; ITAE; ITGAE; MGC141996; Mucosal lymphocyte 1 antigen Specification REACTIVITY: H SENSITIVITY: Endogenous Source/Isotype: Rabbit IgG