CST, 95855S, COL1A2 Antibody

Polyclonal Antibody for studying COL1A2. Validated for Western Blotting. Highly specific and rigorously validated in-house, COL1A2 Antibody (CST #95855) is ready to ship. Product Usage Information Western Blotting: 1:1000 Storage Supplied in 10 mM sodium HEPES (pH 7.5), 150 mM NaCl, 100 µg/ml BSA and 50% glycerol. Store at -20°C. Do not aliquot the antibody. Protocol Available protocols: Western Blotting Specificity / Sensitivity COL1A2 Antibody recognizes endogenous levels of total human COL1A2 protein. Species Reactivity: Human Source / Purification Polyclonal antibodies are produced by immunizing animals with a synthetic peptide corresponding to residues surrounding Asn507 of human COL1A2 protein. Antibodies are purified by peptide affinity chromatography. Background Type 1 collagen is the most abundant collagen in many human tissues, including bone, skin, and tendons. It is a trimeric complex comprised of two molecules of COL1A1 (alpha-1 type 1 collagen) and one molecule of COL1A2 (alpha-2 type 1 collagen) (1-3). The loss-of-function mutations in the and genes are a major causative factor for osteogenesis imperfecta (brittle bone disease) (4). Notably, COL1A2 expression levels have also been associated with tumor development in gastric cancer, pancreatic cancer, and chondrosarcoma (5-7). Research studies suggest that upregulation of COL1A2 can generate a modified extracellular matrix environment that promotes cancer cell proliferation, migration, and invasion. Alternate Names alpha 2 type I procollagen; alpha 2(I) procollagen; alpha 2(I)-collagen; Alpha-2 type I collagen; CO1A2; COL1A2; Collagen alpha-2(I) chain; collagen I, alpha-2 polypeptide; collagen of skin, tendon and bone, alpha-2 chain; collagen type I alpha 2 chain; collagen, type I, alpha 2; EDSARTH2; EDSCV; epididymis secretory sperm binding protein; OI4; type I procollagen Specification REACTIVITY: H SENSITIVITY: Endogenous MW (kDa): 165 SOURCE: Rabbit