CST, 96857S, MT-ATP8 (E2W1A) Rabbit Monoclonal Antibody

Monoclonal Antibody for studying MT-ATP8. Validated for Western Blotting,Immunoprecipitation. Available in 2 sizes. Highly specific and rigorously validated in-house, MT-ATP8 (E2W1A) Rabbit Monoclonal Antibody (CST #96857) is ready to ship. Product Usage Information Western Blotting: 1:1000 Immunoprecipitation: 1:50 Storage Supplied in 10 mM sodium HEPES (pH 7.5), 150 mM NaCl, 100 µg/mL BSA, 50% glycerol and less than 0.02% sodium azide. Store at -20°C. Do not aliquot the antibody. Protocol Available protocols: Western Blotting, Immunoprecipitation Specificity / Sensitivity MT-ATP8 (E2W1A) Rabbit Monoclonal Antibody recognizes endogenous levels of total MT-ATP8 protein. Species Reactivity: Human Source / Purification Monoclonal antibody is produced by immunizing animals with a synthetic peptide corresponding to residues surrounding Pro65 of human MT-ATP8 protein. Background Mitochondrially-encoded ATP Synthase Membrane Subunit 8 (MT-ATP8) is a product of , one of 13 protein-encoding genes in the human mitochondrial genome (1). MT-ATP8 comprises one subunit (ATP synthase F subunit 8) of mitochondrial ATP synthase (Complex V), the inner mitochondrial enzyme that catalyzes the final step of oxidative phosphorylation in the electron transport chain (2). Numerous mutations in  have been identified that have deleterious effects on ATP synthase function, some of which manifest as debilitating neuronal and/or neuromuscular diseases, including epilepsy, schizophrenia, autism, ataxia, and various cardiomyopathies (3), underscoring the importance of healthy mitochondrial function to organismal health. Alternate Names A6L; ATP synthase F0 subunit 8; ATP synthase protein 8; ATP8; ATPASE8; F-ATPase subunit 8; mitochondrially encoded ATP synthase 8; MT-ATP8; MTATP8 Specification REACTIVITY: H SENSITIVITY: Endogenous MW (kDa): 9 Source/Isotype: Rabbit IgG