CST, 96905S, MZB1 (E8V4N) Rabbit Monoclonal Antibody

Monoclonal Antibody for studying MEDA-7. Validated for Western Blotting. Available in 2 sizes. Highly specific and rigorously validated in-house, MZB1 (E8V4N) Rabbit Monoclonal Antibody (CST #96905) is ready to ship. Product Usage Information Western Blotting: 1:1000 Storage Supplied in 10 mM sodium HEPES (pH 7.5), 150 mM NaCl, 100 µg/mL BSA, 50% glycerol, and less than 0.02% sodium azide. Store at -20°C. Do not aliquot the antibody. Protocol Available protocols: Western Blotting Specificity / Sensitivity MZB1 (E8V4N) Rabbit Monoclonal Antibody recognizes endogenous levels of total MZB1 protein. Species Reactivity: Human, Mouse Source / Purification Monoclonal antibody is produced by immunizing animals with a synthetic peptide corresponding to residues surrounding Leu113 of human MZB1 protein. Background Marginal zone B- and B1-cell-specific protein (MZB1) is an ER-resident chaperone protein that is expressed by marginal zone B cells and during plasma cell differentiation (1,2). MZB1 possesses oxidoreductase activity that assists in the proper folding, assembly, and secretion of mature IgM by plasma cells (1,3). Research studies have demonstrated that loss of MZB1 expression compromises antibody secretion and humoral immune responses (4). Alternate Names caspase-2 binding protein; FLJ32987; HSPC190; marginal zone B and B1 cell specific protein; Marginal zone B- and B1-cell-specific protein; MEDA-7; MEDA7; Mesenteric estrogen-dependent adipose 7; mesenteric oestrogen-dependent adipose gene- 7; MGC29506; MZB1; PACAP; pERp1; plasma cell-induced ER protein 1; Plasma cell-induced resident endoplasmic reticulum protein; Plasma cell-induced resident ER protein; Proapoptotic caspase adapter protein; proapoptotic caspase adaptor protein Specification REACTIVITY: H M SENSITIVITY: Endogenous MW (kDa): 20 Source/Isotype: Rabbit IgG