CST, 97450S, IFN-beta1 (D2J1D) Rabbit Monoclonal Antibody

Monoclonal Antibody for studying IFN-beta1 mouse. Validated for Western Blotting. Available in 2 sizes. Highly specific and rigorously validated in-house, IFN-beta1 (D2J1D) Rabbit Monoclonal Antibody (CST #97450) is ready to ship. Product Usage Information Western Blotting: 1:1000 Storage For a carrier free (BSA and azide free) version of this product see product # 15454 . Protocol Available protocols: Western Blotting Specificity / Sensitivity IFN-beta1 (D2J1D) Rabbit Monoclonal Antibody recognizes endogenous levels of total IFN-β1 protein. Species Reactivity: Mouse Source / Purification Monoclonal antibody is produced by immunizing animals with recombinant mouse IFN-β1 protein. Background The type I interferon (IFN) family includes IFN-β1 and IFN-α1 through IFN-α13 in humans and IFN-α1 through IFN-α14 in mice. Type I IFN is produced following detection of pathogen-associated molecular patterns (PAMPs) and is important for induction of antiviral genes, activation of dendritic cells, and initiation of adaptive immunity (1, 2). Type I IFNs signal through the IFN alpha receptor (IFNAR), which is a heterodimer composed of IFNAR1 and IFNAR2. Activation of IFNAR leads to formation of the nuclear complex IFN-stimulated gene factor 3 (ISGF3), which consists of STAT1, STAT2, and IRF-9 (3, 4). ISGF3 binds to IFN-stimulated response elements (ISREs) to initiate transcription of interferon-stimulated genes (3). Alternate Names Ifb; IFN-b; IFN-beta; Ifnb; Ifnb1; Interferon beta; interferon beta 1, fibroblast Specification REACTIVITY: M SENSITIVITY: Endogenous MW (kDa): 24, 26 Source/Isotype: Rabbit IgG