CST, 97597S, CD180/RP105 Antibody

Polyclonal Antibody for studying CD180. Validated for Western Blotting. Highly specific and rigorously validated in-house, CD180/RP105 Antibody (CST #97597) is ready to ship. Product Usage Information Western Blotting: 1:1000 Storage Supplied in 10 mM sodium HEPES (pH 7.5), 150 mM NaCl, 100 µg/ml BSA and 50% glycerol. Store at -20°C. Do not aliquot the antibody. Protocol Available protocols: Western Blotting Specificity / Sensitivity CD180/RP105 Antibody recognizes endogenous levels of total CD180/RP105 protein. Species Reactivity: Human Source / Purification Polyclonal antibodies are produced by immunizing animals with a synthetic peptide corresponding to residues surrounding Asp483 of human CD180/RP105 protein. Antibodies are purified by peptide affinity chromatography. Background CD180/RP105 is a type-I transmembrane glycoprotein that is restricted to expression in mature B cells. Research studies have shown that CD180 engages signaling cascades in mature B cells that drive cell proliferation (1-3). Indeed, CD180 functions with TLR4 as an LPS receptor on B cells and, upon binding LPS, transmits proliferation and survival signals that require the Vav family of guanine nucleotide exchange factors (4-6). Alternate Names CD180; CD180 antigen; CD180 molecule; LY64; Ly78; Lymphocyte antigen 64; lymphocyte antigen-64, radioprotective, 105kDa; MGC126233; MGC126234; Radioprotective 105 kDa protein; RP105 Specification REACTIVITY: H SENSITIVITY: Endogenous MW (kDa): 98 SOURCE: Rabbit