CST, 97630T, TSLP (D7U1X) Rabbit Monoclonal Antibody

Monoclonal Antibody for studying TSLP. Validated for Western Blotting. Available in 2 sizes. Highly specific and rigorously validated in-house, TSLP (D7U1X) Rabbit Monoclonal Antibody (CST #97630) is ready to ship. Product Usage Information Western Blotting: 1:1000 Storage Supplied in 10 mM sodium HEPES (pH 7.5), 150 mM NaCl, 100 µg/ml BSA, 50% glycerol and less than 0.02% sodium azide. Store at -20°C. Do not aliquot the antibody. Protocol Available protocols: Western Blotting Specificity / Sensitivity TSLP (D7U1X) Rabbit Monoclonal Antibody recognizes endogenous levels of total TSLP protein. This antibody recognizes a 70 kDa protein of unknown identity. Species Reactivity: Human Source / Purification Monoclonal antibody is produced by immunizing animals with recombinant human TSLP protein. Background Thymic stromal lymphopoietin (TSLP) is a cytokine produced by epithelial cells at barrier surfaces and granulocytes (1). TSLP acts on dendritic cells, lymphocytes, and granulocytes by binding to a heterodimer composed of TSLP receptor (TSLPR) and IL-7Rα (2-5). Constitutive expression of TSLP at barrier surfaces contributes to homeostasis by promoting generation of noninflammatory dendritic cells (6). TSLP promotes the differentiation of Th2 cells and type 2 immune responses both in response to helminth infection and in the context of atopic diseases, including asthma and atopic dermatitis (1,7-12). Alternate Names Thymic stromal lymphopoietin; TSLP Specification REACTIVITY: H SENSITIVITY: Endogenous MW (kDa): 19, 22 Source/Isotype: Rabbit IgG