CST, 98204S, Integrin alpha5 (D7B7G) Rabbit Monoclonal Antibody

Monoclonal Antibody for studying ITGA5. Validated for Western Blotting. Available in 2 sizes. Highly specific and rigorously validated in-house, Integrin alpha5 (D7B7G) Rabbit Monoclonal Antibody (CST #98204) is ready to ship. Product Usage Information Western Blotting: 1:1000 Storage Supplied in 10 mM sodium HEPES (pH 7.5), 150 mM NaCl, 100 µg/ml BSA, 50% glycerol and less than 0.02% sodium azide. Store at -20°C. Do not aliquot the antibody. Protocol Available protocols: Western Blotting Specificity / Sensitivity Integrin alpha5 (D7B7G) Rabbit Monoclonal Antibody recognizes endogenous levels of total Integrin α5 protein. Species Reactivity: Human, Mouse, Rat, Hamster, Monkey Source / Purification Monoclonal antibody is produced by immunizing animals with a synthetic peptide corresponding to residues surrounding Gly117 of human Integrin α5 protein. Background Integrins are α/β heterodimeric cell surface receptors that play a pivotal role in cell adhesion and migration, as well as in growth and survival (1,2). The integrin family contains at least 18 α and 8 β subunits that form 24 known integrins with distinct tissue distribution and overlapping ligand specificities (3). Integrins not only transmit signals to cells in response to the extracellular environment (outside-in signaling), but also sense intracellular cues to alter their interaction with the extracellular environment (inside-out signaling) (1,2). Integrin α5/β1 is involved in multiple biological processes including embryonic development, angiogenesis and tumor metastasis (4,5). By interaction with its fibronectin ligand, α5/β1 transduces signals that regulate cell adhesion, migration, matrix assembly and cytoskeletal organization (6). Alternate Names CD49 antigen-like family member E; CD49e; Fibronectin receptor subunit alpha; fibronectin receptor, alpha polypeptide; fibronectin receptor, alpha subunit; FNRA; Integrin alpha-5; Integrin alpha-5 heavy chain; Integrin alpha-5 light chain; Integrin alpha-F; integrin subunit alpha 5; integrin, alpha 5 (fibronectin receptor, alpha polypeptide); ITA5; ITGA5; ITGA5/SLC9B1 fusion; very late activation protein 5, alpha subunit; VLA-5; VLA5A Specification REACTIVITY: H M R Hm Mk SENSITIVITY: Endogenous MW (kDa): 150 Source/Isotype: Rabbit IgG