CST, 98215T, MSR1 (E7P6W) Rabbit Monoclonal Antibody

Monoclonal Antibody for studying MSR1 mouse. Validated for Immunohistochemistry (Paraffin). Available in 2 sizes. Highly specific and rigorously validated in-house, MSR1 (E7P6W) Rabbit Monoclonal Antibody (CST #98215) is ready to ship. Product Usage Information Immunohistochemistry (Paraffin): 1:150 - 1:600 Storage Supplied in 10 mM sodium HEPES (pH 7.5), 150 mM NaCl, 100 µg/ml BSA, 50% glycerol and less than 0.02% sodium azide. Store at -20°C. Do not aliquot the antibody. Protocol Available protocols: Immunohistochemistry (Paraffin) Specificity / Sensitivity MSR1 (E7P6W) Rabbit Monoclonal Antibody recognizes endogenous levels of total MSR1 protein. Non-specific staining was observed in mouse testis and pancreatic islets by immunohistochemistry. Species Reactivity: Mouse Source / Purification Monoclonal antibody is produced by immunizing animals with recombinant protein specific to the carboxy terminus of mouse MSR1 protein. Background Macrophage Scavenger receptor types I and II (MSR1, also known as SCARA1) are members of the class A macrophage scavenger receptor family. These proteins bind large quantities of modified lipoproteins and promote endocytosis. Upregulation of MSR1 in infiltrating myeloid cells may mediate clearance of specific damage signals in response to tissue injury, including ischemic stroke (1). MSR1 germline mutations are also associated with increased prostate cancer susceptibility in some patient cohorts (2). MSR1 is observed to be upregulated in differentiated THP-1 cells (3). Alternate Names CD204; Macrophage acetylated LDL receptor I and II; macrophage scavenger receptor 1; Macrophage scavenger receptor types I and II; MRS-A; MSR; MSR-A; Msr1; MSRE; Scara1; Scavenger receptor type A; Scvr; SR-A; SR-AI; SR-AII Specification REACTIVITY: M SENSITIVITY: Endogenous Source/Isotype: Rabbit IgG