CST, 98245S, CD21/CR2 Antibody

Polyclonal Antibody for studying CR2. Validated for Western Blotting. Highly specific and rigorously validated in-house, CD21/CR2 Antibody (CST #98245) is ready to ship. Product Usage Information Western Blotting: 1:1000 Storage Supplied in 10 mM sodium HEPES (pH 7.5), 150 mM NaCl, 100 µg/ml BSA and 50% glycerol. Store at -20°C. Do not aliquot the antibody. Protocol Available protocols: Western Blotting Specificity / Sensitivity CD21/CR2 Antibody recognizes endogenous levels of total CD21/CR2 protein. Species Reactivity: Human Source / Purification Polyclonal antibodies are produced by immunizing animals with a synthetic peptide corresponding to residues surrounding Asp430 of human CD21/CR2 protein. Antibodies are purified by protein A and peptide affinity chromatography. Background Complement receptor type 2 (CD21/CR2) is a type 1 transmembrane glycoprotein whose expression is largely restricted to B lymphocytes and follicular dendritic cells (1,2). Research studies have shown that CD21/CR2 functions to bind the complement fragments iC3b, C3dg, and C3d, which function to activate the alternative complement pathway and MAC formation (3,4). In addition to its function as a complement receptor, CD21/CR2 also functions as the B lymphocyte receptor for Epstein-Barr virus (5) and interferon alpha (6). Research studies have also shown that CD21/CR2 participates in B cell activation, proliferation, and protection from apoptosis through its association with components of the B cell coreceptor signaling complex such as CD19 and CD21 (7-9). Alternate Names C3DR; CD21; Complement C3d receptor; complement C3d receptor 2; complement component (3d/Epstein Barr virus) receptor 2; complement component 3d receptor 2; Complement receptor type 2; CR; CR2; CVID7; EBV receptor; Epstein-Barr virus receptor; SLEB9 Specification REACTIVITY: H SENSITIVITY: Endogenous MW (kDa): 150 SOURCE: Rabbit