CST, 98455S, Coronin 1A (D6K5B) Rabbit Monoclonal Antibody (PE Conjugate)

Monoclonal Antibody for studying coronin 1A. Validated for Flow Cytometry (Fixed/Permeabilized). Highly specific and rigorously validated in-house, Coronin 1A (D6K5B) Rabbit Monoclonal Antibody (PE Conjugate) (CST #98455) is ready to ship. Product Usage Information Flow Cytometry (Fixed/Permeabilized): 1:50 Storage Supplied in PBS (pH 7.2), less than 0.1% sodium azide and 2 mg/ml BSA. Store at 4°C. Do not aliquot the antibody. Protect from light. Do not freeze. Protocol Available protocols: Flow Cytometry (Fixed/Permeabilized) Specificity / Sensitivity Coronin 1A (D6K5B) Rabbit Monoclonal Antibody (PE Conjugate) recognizes endogenous levels of total coronin 1A protein. Based on the sequence of the immunogenic peptide, this antibody conjugate is not expected to cross-react with other coronin protein family members. Species Reactivity: Human, Mouse Source / Purification Monoclonal antibody is produced by immunizing animals with a synthetic peptide corresponding to residues surrounding Val200 of human coronin 1A protein. Background The coronin family of actin-binding proteins regulates a variety of cellular functions, including migration, phagocytosis, and cytokinesis. Coronin 1A is highly expressed in lymphocytes, and is required for appropriate immune regulation in mice and humans. Researchers are investigating coronin 1A as a potential therapeutic target for autoimmune diseases and lymphoid cancers (1,2). Coronin 1A affects bone resorption through its regulation of lysosome fusion and secretion of cathepsin K in osteoclasts (3). In the nervous system, coronin 1A has been shown to regulate GPCR signaling and neurite outgrowth (4,5). Alternate Names CLABP; Clipin-A; CLIPINA; COR1A; CORO1; CORO1A; coronin 1A; coronin-1; Coronin-1A; Coronin-like protein A; Coronin-like protein p57; coronin, actin binding protein, 1A; coronin, actin-binding protein, 1A; coronin, actin-binding, 1A; FLJ41407; HCORO1; IMD8; MGC117380; p57; TACO; Tryptophan aspartate-containing coat protein Specification REACTIVITY: H M SENSITIVITY: Endogenous Source/Isotype: Rabbit IgG