CST, 98971S, Ceruloplasmin (D7Q5W) Rabbit Monoclonal Antibody

Monoclonal Antibody for studying Ceruloplasmin. Validated for Western Blotting,Immunoprecipitation. Available in 2 sizes. Highly specific and rigorously validated in-house, Ceruloplasmin (D7Q5W) Rabbit Monoclonal Antibody (CST #98971) is ready to ship. Product Usage Information Western Blotting: 1:1000 Immunoprecipitation: 1:200 Storage Supplied in 10 mM sodium HEPES (pH 7.5), 150 mM NaCl, 100 µg/ml BSA, 50% glycerol and less than 0.02% sodium azide. Store at -20°C. Do not aliquot the antibody. Protocol Available protocols: Western Blotting, Immunoprecipitation Specificity / Sensitivity Ceruloplasmin (D7Q5W) Rabbit Monoclonal Antibody recognizes endogenous levels of total Ceruloplasmin protein. Species Reactivity: Human Source / Purification Monoclonal antibody is produced by immunizing animals with a synthetic peptide corresponding to residues surrounding Phe727 of human Ceruloplasmin protein. Background Ceruloplasmin is a copper-binding glycoprotein with ferroxidase activity. It oxidizes Fe to Fe , facilitating iron transport across the cell membrane (1). Mutation in Ceruloplasmin causes aceruloplasminemia, an autosomal recessive disorder of iron metabolism characterized by iron accumulation in the brain as well as visceral organs, resulting in retinal degeneration, diabetes mellitus and neurological disturbances (2,3). Ceruloplasmin level in serum has been explored as a diagnostic marker for Wilson disease and ischemic heart disease (4,5). Alternate Names CERU; Ceruloplasmin; ceruloplasmin (ferroxidase); CP; CP-2; Ferroxidase Specification REACTIVITY: H SENSITIVITY: Endogenous MW (kDa): 140 Source/Isotype: Rabbit IgG