CST, 99258S, UQCRC2 (F8Y5N) Rabbit Monoclonal Antibody

Monoclonal Antibody for studying UQCRC2. Validated for Western Blotting,Simple Western™,Immunoprecipitation. Available in 2 sizes. Highly specific and rigorously validated in-house, UQCRC2 (F8Y5N) Rabbit Monoclonal Antibody (CST #99258) is ready to ship. Product Usage Information Western Blotting: 1:1000 Simple Western™: 1:50 - 1:250 Immunoprecipitation: 1:50 Storage Supplied in 10 mM sodium HEPES (pH 7.5), 150 mM NaCl, 100 µg/mL BSA, 50% glycerol, and less than 0.02% sodium azide. Store at -20°C. Do not aliquot the antibody. Protocol Available protocols: Western Blotting, Immunoprecipitation Specificity / Sensitivity UQCRC2 (F8Y5N) Rabbit Monoclonal Antibody recognizes endogenous levels of total UQCRC2 protein. Species Reactivity: Human, Mouse, Rat Source / Purification Monoclonal antibody is produced by immunizing animals with a synthetic peptide corresponding to residues near the carboxy terminus of human UQCRC2 protein. Background Ubiquinol-cytochrome c reductase complex core protein 2 (UQCRC2), also known as cytochrome b-c1 complex subunit 2, is a component of the ubiquinol-cytochrome c oxidoreductase complex (Complex III) in the mitochondrial electron transport chain (1,2). Studies show that AMPK increases UQCRC2 expression to promote mitophagy, protecting the liver against alcohol-induced injury (3). In addition, overexpression of UQCRC2 was shown to inhibit gastric cancer cell proliferation, invasion, and migration (4). Alternate Names Complex III subunit 2; Core protein II; Cytochrome b-c1 complex subunit 2, mitochondrial; cytochrome bc-1 complex core protein II; MC3DN5; QCR2; ubiquinol-cytochrome c reductase core protein 2; ubiquinol-cytochrome c reductase core protein II; Ubiquinol-cytochrome-c reductase complex core protein 2; UQCR2; UQCRC2 Specification REACTIVITY: H M R SENSITIVITY: Endogenous MW (kDa): 48 Source/Isotype: Rabbit IgG