CST, 99613S, SELENBP1 (F7V8F) Rabbit Monoclonal Antibody

Monoclonal Antibody for studying SELENBP1. Validated for Western Blotting,Simple Western™. Available in 2 sizes. Highly specific and rigorously validated in-house, SELENBP1 (F7V8F) Rabbit Monoclonal Antibody (CST #99613) is ready to ship. Product Usage Information Western Blotting: 1:1000 Simple Western™: 1:10 - 1:50 Storage Supplied in 10 mM sodium HEPES (pH 7.5), 150 mM NaCl, 100 µg/mL BSA, 50% glycerol, and less than 0.02% sodium azide. Store at -20°C. Do not aliquot the antibody. Protocol Available protocols: Western Blotting Specificity / Sensitivity SELENBP1 (F7V8F) Rabbit Monoclonal Antibody recognizes endogenous levels of total SELENBP1 protein. Species Reactivity: Human, Mouse, Rat Source / Purification Monoclonal antibody is produced by immunizing animals with a synthetic peptide corresponding to residues surrounding Pro15 of human SELENBP1 protein. Background Selenium-binding protein 1 (SELENBP1), also known as SBP, is a widely expressed methanethiol oxidase, an enzyme capable of converting methanethiol to hydrogen sulfide, hydrogen peroxide, and formaldehyde (1). SELENBP1 is able to bind selenium, though it is not required for its enzymatic activity; copper, however, is a required cofactor (2). SELENBP1 is reported to act as a tumor suppressor; its expression is downregulated in several types of cancer, such as lung, bladder, and colorectal cancer (3-5). overexpression is associated with schizophrenia. The prefrontal cortex and blood of schizophrenia patients show elevated gene expression levels, and transgenic mice engineered to express human SELENBP1 in the frontal cortex exhibit a subset of schizophrenia-like phenotypes (6,7). Alternate Names 56 kDa selenium-binding protein; EHMTO; epididymis secretory sperm binding protein Li 134P; FLJ13813; HEL-S-134P; hSBP; hSP56; LPSB; Methanethiol oxidase; MTO; SBP; SBP1; SBP56; SELENBP1; selenium binding protein 1; Selenium-binding protein 1; SP56 Specification REACTIVITY: H M R SENSITIVITY: Endogenous MW (kDa): 52 Source/Isotype: Rabbit IgG