Merck, DN25-5G, Deoxyribonuclease I from bovine pancreas

DNase I, or Deoxyribonuclease I, is an endonuclease isolated from bovine pancreas. •Our DNase I Digests double str and single stranded DNA into oligo and mononucleotides. •Bovine pancreatic DNase exists as four isozymes, having isoelectric points for A, B, C and D: 5.22, 4.96, 5.06 and 4.78.3. The predominant form is A, with smaller amounts of B and C, and only minor amount of D. •DNase I structure resembles the structure of to exonuclease III. It includes two central ß sheets. Each β sheet is composed of six β-strands. This complex of β sheets is surrounded by extensive loop and α-helical regions. This enzyme shares structural similarity to exonuclease III.[1]