Merck, P0899-1G, Poly-D-lysine hydrobromide

Poly-D-lysine hydrobromide (PDLHB) is a water-soluble, positively charged polyamino acid that has a variety of applications in biology and biomedicine. PDLHB is commonly used to promote cell adhesion to surfaces, which is essential for cell culture, microscopy, and neuroscience research. PDLHB is also used in tissue engineering and drug delivery research. Poly-D-lysine′s primary function lies in facilitating robust cell adhesion to surfaces, leveraging its positive charge to attract and anchor cells by binding with negatively charged proteins and molecules on cell surfaces. This feature is especially valuable when coating cell culture dishes and plates, where it proves essential for ensuring reliable cell adhesion, especially for challenging cell types like primary cells and specific cancer cells. In microscopy and neuroscience applications, PDLHB-coated substrates come to the forefront, allowing for the seamless attachment of cells, tissues, and neurons to slides and culture dishes. This fosters meticulous observation and exploration of these crucial biological components, making PDLHB an indispensable resource for in-depth investigations. Furthermore, PDLHB extends its utility to tissue engineering by supporting the creation of cell growth scaffolds. These PDLHB-coated scaffolds closely replicate the natural cellular environment, promoting effective healing and regeneration. In the realm of drug delivery, PDLHB plays a pivotal role, acting as a protective shield for encapsulated drugs and precisely guiding them to specific cells and tissues. This versatile and biocompatible polymer is an invaluable asset, elevating the standards of cell culture and biochemical research+R8 within the field of biology and biomedicine.