Proteintech, 15065-1-AP, ANAPC11 Polyclonal antibody

Size: 20ul / 150ul The ANAPC11 (15065-1-AP) by Proteintech is a Polyclonal antibody targeting ANAPC11 in WB, ELISA applications with reactivity to human, mouse, rat samples 15065-1-AP targets ANAPC11 in WB, ELISA applications and shows reactivity with human, mouse, rat samples. Tested Applications Positive WB detected in: mouse testis tissue, rat testis tissue Recommended dilution Western Blot (WB): WB : 1:500-1:1000 Background Information Anaphase-promoting complex subunit 11 (ANAPC11) is a core catalytic subunit of the anaphase-promoting complex/cyclosome (APC/C). ANAPC11 is involved in the ubiquitination and degradation of key cell cycle regulators, including cyclin B and securin, facilitating the transition from metaphase to anaphase during cell division (PMID: 11739784; 18485873). ANAPC11 also mediates the ubiquitination and degradation of the Forkhead transcription factor FOXO3, promoting cell proliferation and lymph node metastasis in urothelial bladder cancer (PMID: 37573356). Specification Tested Reactivity: human, mouse, rat Host / Isotype: Rabbit / IgG Class: Polyclonal Type: Antibody Immunogen: CatNo: Ag7069 Product name: Recombinant human ANAPC11 protein Source: e coli. -derived, PGEX-4T Tag: GST Domain: 1-196 aa of BC000607 Sequence: MKVKIKCWNGVATWLWVANDENCGICRMAFNGCCPDCPLHGESISRCLGWCPQPVPVLGGRAHPQVPINTASPTPGQHTGSLMSREESSRSPDPTPPALDQETSSLLRCTSPWCLDHSCDLFGITDQVSADGPRACRQGARRRLPAGVGPVLPLLPHALHPQVAARTAGAAALPHVPPGMEVQGVRPDLALAGGAS Predict reactive species Full Name: anaphase promoting complex subunit 11 Calculated Molecular Weight: 21 kDa, 10 kDa Observed Molecular Weight: 21 kDa GenBank Accession Number: BC000607 Gene Symbol: APC11 Gene ID (NCBI): 51529 Conjugate: Unconjugated Form: Liquid Purification Method: Antigen affinity purification UNIPROT ID: Q9NYG5 Storage Buffer: PBS with 0.02% sodium azide and 50% glycerol, pH 7.3. Storage Conditions: Store at -20°C. Stable for one year after shipment. Aliquoting is unnecessary for -20 o C storage. 20ul sizes contain 0.1% BSA.