Proteintech, 28379-1-AP, CYP19A1 Polyclonal antibody

Size: 20ul / 150ul The CYP19A1 (28379-1-AP) by Proteintech is a Polyclonal antibody targeting CYP19A1 in WB, ELISA applications with reactivity to human samples 28379-1-AP targets CYP19A1 in WB, ELISA applications and shows reactivity with human samples. Tested Applications Positive WB detected in: HL-60 cells, K-562 cells Recommended dilution Western Blot (WB): WB : 1:500-1:2000 Background Information CYP19A1(Cytochrome P450 19A1) is also named as ARO1(aromatase), CYAR, CYP19, estrogen synthase and belongs to the cytochrome P450 family. It is a terminal enzyme which transforms irreversibly androgens into estrogens and it is present in the endoplasmic reticulum of numerous tissues(PMID:16406261). The gene encodes a protein with the molecular weight between 46 kDa and 69 kDa(PMID:8129748) and the protein can be glycosylated, but the level of glycosylation does not seem to be essential for CYP19A1 activity(PMID:12606587). Brain aromatase may be neuroprotective by increasing the local estrogen levels in injured neurons so that genetic variation in the brain aromatase gene may modify the risk for AD(PMID:16767510). Specification Tested Reactivity: human Host / Isotype: Rabbit / IgG Class: Polyclonal Type: Antibody Immunogen: CatNo: Ag29004 Product name: Recombinant human CYP19A1 protein Source: e coli. -derived, PGEX-4T Tag: GST Domain: 241-400 aa of BC035959 Sequence: YKKYEKSVKDLKDAIEVLIAEKRRRISTEEKLEECMDFATELILAEKRGDLTRENVNQCILEMLIAAPDTMSVSLFFMLFLIAKHPNVEEAIIKEIQTVIGERDIKIDDIQKLKVMENFIYESMRYQPVVDLVMRKALEDDVIDGYPVKKGTNIILNIGR Predict reactive species Full Name: cytochrome P450, family 19, subfamily A, polypeptide 1 Observed Molecular Weight: 58-60 kDa GenBank Accession Number: BC035959 Gene Symbol: CYP19A1 Gene ID (NCBI): 1588 RRID: AB_3669657 Conjugate: Unconjugated Form: Liquid Purification Method: Antigen affinity purification UNIPROT ID: P11511 Storage Buffer: PBS with 0.02% sodium azide and 50% glycerol, pH 7.3. Storage Conditions: Store at -20°C. Stable for one year after shipment. Aliquoting is unnecessary for -20 o C storage. 20ul sizes contain 0.1% BSA.